Gmds MGI Mouse Gene Detail - MGI:1891112 - GDP-mannose 4, 6-dehydratase

Symbol

Gmds
Name

GDP-mannose 4, 6-dehydratase
Synonyms

MGC:18773

Feature Type

protein coding gene
IDs

MGI:1891112
NCBI Gene: 218138
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr13:32003562-32522723 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 13.52 cM
Mapping Data

2 experiments

SNPs within 2kb

10287 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891112	protein coding gene	Chr13:32003562-32522744 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0020424	protein coding gene	Chr13:29763588-30306729 (-)
A/J	MGP_AJ_G0020379	protein coding gene	Chr13:28953608-29491117 (-)
AKR/J	MGP_AKRJ_G0020356	protein coding gene	Chr13:29587740-30137507 (-)
BALB/cJ	MGP_BALBcJ_G0020374	protein coding gene	Chr13:29050792-29581884 (-)
C3H/HeJ	MGP_C3HHeJ_G0020177	protein coding gene	Chr13:29589576-30136488 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020810	protein coding gene	Chr13:30770598-31332345 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018401	protein coding gene	Chr13:27325744-27841191 (-)
CAST/EiJ	MGP_CASTEiJ_G0019694	protein coding gene	Chr13:29279555-29829104 (-)
CBA/J	MGP_CBAJ_G0020133	protein coding gene	Chr13:32077758-32681528 (-)
DBA/2J	MGP_DBA2J_G0020255	protein coding gene	Chr13:28476590-29007582 (-)
FVB/NJ	MGP_FVBNJ_G0020240	protein coding gene	Chr13:28087158-28603556 (-)
LP/J	MGP_LPJ_G0020332	protein coding gene	Chr13:29979200-30536887 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020266	protein coding gene	Chr13:32190687-32743969 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020851	protein coding gene	Chr13:29256772-29787312 (-)
PWK/PhJ	MGP_PWKPhJ_G0019449	protein coding gene	Chr13:28640477-29178999 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0019270	protein coding gene	Chr13:28149758-28693715 (-)
WSB/EiJ	MGP_WSBEiJ_G0019756	protein coding gene	Chr13:29546702-30092927 (-)

Human Ortholog

GMDS, GDP-mannose 4,6-dehydratase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GMDS, GDP-mannose 4,6-dehydratase
Synonyms

GMD, SDR3E1
Links

HGNC:4369

NCBI Gene ID: 2762

neXtProt AC: NX_O60547

UniProt: O60547
Chr Location

6p25.3; chr6:1623806-2245605 (-) GRCh38

MGI Vertebrate Homology

Gmds stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GMDS
Gene Tree

Gmds

Diseases

1 with human GMDS associations

				Human Disease	Mouse Models
				open-angle glaucoma IDs open-angle glaucoma DOID:1067 EFO:0004190 ICD10CM:H40.1 ICD9CM:365.1 ICD9CM:365.10 ICD9CM:365.13 MESH:D005902 NCI:C34641 OMIM:137750 OMIM:177700 OMIM:602429 OMIM:603383 OMIM:606689 OMIM:608695 OMIM:608696 OMIM:609745 OMIM:609887 OMIM:610535 OMIM:611274 OMIM:611276 OMIM:613100 UMLS_CUI:C0017612

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

47 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Gene trapped

6
Radiation induced

1
Targeted

2
Genomic Mutations

2 involving Gmds
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

16
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

890
Tissues

108
cDNA Data

35
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gmds

ZFIN gmds

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All Sequences

42
RefSeq

4
UniProt

2
CCDS

CCDS26426.1

Ensembl

ENSMUSG00000038372 (Evidence)
NCBI Gene

218138

			Length	Strain/Species	Flank
genomic	ENSMUSG00000038372	Ensembl Gene Model \| MGI Sequence Detail	519162	C57BL/6J	± kb
transcript	ENSMUST00000041859	Ensembl \| MGI Sequence Detail	1713	Not Applicable
polypeptide	ENSMUSP00000036696	Ensembl \| MGI Sequence Detail	372	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000008067 GDP-mannose 4,6 dehydratase

(term hierarchy)
EC

4.2.1.47
InterPro Domains

IPR006368 GDP-mannose 4,6-dehydratase

IPR016040 NAD(P)-binding domain

IPR036291 NAD(P)-binding domain superfamily

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All nucleic 36

cDNA 35

Primer pair 1

Microarray probesets 6

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MGI:2145537, MGI:2384985

Summaries

All 46

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 15
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gmds:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121997	Chr13:32522548-32522643 (-)	127 bp
Tssr121996	Chr13:32522537-32522547 (-)	181 bp
Tssr121995	Chr13:32522483-32522525 (-)	219 bp
Tssr4034	Chr13:32398130-32398135 (-)	124,590 bp
Tssr121994	Chr13:32398083-32398110 (-)	124,626 bp
Tssr121993	Chr13:32168806-32168810 (-)	353,915 bp
Tssr121992	Chr13:32004570-32004603 (-)	518,136 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24