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Kcne4 Gene Detail
Summary
  • Symbol
    Kcne4
  • Name
    potassium voltage-gated channel, Isk-related subfamily, gene 4
  • Synonyms
    MiRP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891125
    NCBI Gene: 57814
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:78794628-78797749 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 40.89 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891125
 protein coding gene Chr1:78794475-78797749 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016203
 protein coding gene Chr1:79578305-79581588 (+)
A/J MGP_AJ_G0016186
 protein coding gene Chr1:76769802-76773096 (+)
AKR/J MGP_AKRJ_G0016143
 protein coding gene Chr1:78885997-78889271 (+)
BALB/cJ MGP_BALBcJ_G0016141
 protein coding gene Chr1:76867505-76870795 (+)
C3H/HeJ MGP_C3HHeJ_G0015971
 protein coding gene Chr1:79235874-79239164 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016594
 protein coding gene Chr1:82657434-82660704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014314
 protein coding gene Chr1:72179818-72183083 (+)
CAST/EiJ MGP_CASTEiJ_G0015556
 protein coding gene Chr1:78615030-78618306 (+)
CBA/J MGP_CBAJ_G0015945
 protein coding gene Chr1:85359902-85363172 (+)
DBA/2J MGP_DBA2J_G0016046
 protein coding gene Chr1:76088167-76091437 (+)
FVB/NJ MGP_FVBNJ_G0016049
 protein coding gene Chr1:75248773-75252029 (+)
LP/J MGP_LPJ_G0016118
 protein coding gene Chr1:80697593-80700884 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016069
 protein coding gene Chr1:88577889-88581159 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016641
 protein coding gene Chr1:79007336-79010588 (+)
PWK/PhJ MGP_PWKPhJ_G0015342
 protein coding gene Chr1:75550657-75553945 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015120
 protein coding gene Chr1:78331669-78334966 (+)
WSB/EiJ MGP_WSBEiJ_G0015617
 protein coding gene Chr1:78793348-78796638 (+)



Homology
more
  • Human Ortholog
    KCNE4, potassium voltage-gated channel subfamily E regulatory subunit 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNE4, potassium voltage-gated channel subfamily E regulatory subunit 4
  • Synonyms
    MIRP3
  • Links
    NCBI Gene ID: 23704
    neXtProt AC: NX_Q8WWG9
    UniProt: Q8WWG9

  • Chr Location
    2q36.1; chr2:223052190-223198399 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous deletion of this gene impairs cardiac ventricular repolarization in an age and sex-dependent manner, with a prolonged QT interval only occurring similarly in both males and females after female menopause.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    6
  • cDNA Data
    16
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57814 NCBI Gene Model | MGI Sequence Detail 3122 C57BL/6J ±  kb
    transcript NM_021342 RefSeq | MGI Sequence Detail 2524 C57BL/6  
    polypeptide Q9WTW3 UniProt | EBI | MGI Sequence Detail 170 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000009258 potassium voltage-gated channel subfamily E member 4
      (term hierarchy)
    • InterPro Domains
      IPR000369 Potassium channel, voltage-dependent, beta subunit, KCNE
    • GlyGen
      Q9WTW3 2 sites
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2138590
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 2
      Gene Ontology 11
      Phenotypes 8
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:352579 Sole L, et al., Functional Consequences of the Variable Stoichiometry of the Kv1.3-KCNE4 Complex. Cells. 2020 May 2;9(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory