Tbx19 MGI Mouse Gene Detail - MGI:1891158

Symbol

Tbx19
Name

T-box 19
Synonyms

D1Ertd754e, Tpit

Feature Type

protein coding gene
IDs

MGI:1891158
NCBI Gene: 83993
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:164965424-164988342 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 72.47 cM, cytoband H2
Mapping Data

4 experiments

SNPs within 2kb

863 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891158	protein coding gene	Chr1:164965403-164988342 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016688	protein coding gene	Chr1:170605825-170631842 (-)
A/J	MGP_AJ_G0016669	protein coding gene	Chr1:163650660-163676280 (-)
AKR/J	MGP_AKRJ_G0016635	protein coding gene	Chr1:168603421-168628256 (-)
BALB/cJ	MGP_BALBcJ_G0016630	protein coding gene	Chr1:164142053-164164695 (-)
C3H/HeJ	MGP_C3HHeJ_G0016454	protein coding gene	Chr1:168823134-168848912 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017091	protein coding gene	Chr1:176332947-176359118 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014800	protein coding gene	Chr1:155570351-155590738 (-)
CAST/EiJ	MGP_CASTEiJ_G0016034	protein coding gene	Chr1:168451736-168476130 (-)
CBA/J	MGP_CBAJ_G0016429	protein coding gene	Chr1:182605385-182632769 (-)
DBA/2J	MGP_DBA2J_G0016535	protein coding gene	Chr1:162542165-162565030 (-)
FVB/NJ	MGP_FVBNJ_G0016533	protein coding gene	Chr1:160995215-161020056 (-)
LP/J	MGP_LPJ_G0016606	protein coding gene	Chr1:171684363-171708405 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016558	protein coding gene	Chr1:190116472-190142186 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017127	protein coding gene	Chr1:168454539-168478501 (-)
PWK/PhJ	MGP_PWKPhJ_G0015820	protein coding gene	Chr1:161742453-161766250 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015607	protein coding gene	Chr1:167318507-167342167 (-)
WSB/EiJ	MGP_WSBEiJ_G0016096	protein coding gene	Chr1:168614700-168637472 (-)

Human Ortholog

TBX19, T-box transcription factor 19

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TBX19, T-box transcription factor 19
Synonyms

dJ747L4.1, TBS19, TPIT
Links

HGNC:11596

NCBI Gene ID: 9095

neXtProt AC: NX_O60806

UniProt: O60806
Chr Location

1q24.2; chr1:168280877-168314426 (+) GRCh38

MGI Vertebrate Homology

Tbx19 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TBX19
Gene Tree

Tbx19

Diseases

1 with Tbx19 mouse models; 3 with human TBX19 associations

Human Disease

Mouse Models

adrenocorticotropic hormone deficiency

IDs

View 1 model

alcohol dependence

IDs

inherited metabolic disorder

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

10 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Endonuclease-mediated

1
Targeted

2
Genomic Mutations

2 involving Tbx19
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

The phenotype of homozygous null mice is similar to that of patients with early onset pituitary ACTH deficiency. They are characterized by fasting-induced hypoglycemia due to an impaired pituitary-adrenal axis.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

843
Tissues

98
cDNA Data

18
Literature Summary

40

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tbx19

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All Sequences

41
RefSeq

4
UniProt

2
CCDS

CCDS15439.1

Ensembl

ENSMUSG00000026572 (Evidence)
NCBI Gene

83993

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026572	Ensembl Gene Model \| MGI Sequence Detail	22919	C57BL/6J	± kb
transcript	ENSMUST00000027859	Ensembl \| MGI Sequence Detail	2660	Not Applicable
polypeptide	ENSMUSP00000027859	Ensembl \| MGI Sequence Detail	446	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016147 T-box transcription factor TBX19

(term hierarchy)
InterPro Domains

IPR008967 p53-like transcription factor, DNA-binding domain superfamily

IPR036960 T-box superfamily

IPR001699 T-box transcription factor

IPR046360 T-box transcription factor, DNA-binding domain

IPR002070 Transcription factor, Brachyury

IPR018186 Transcription factor, T-box, conserved site

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All nucleic 24

cDNA 18

Primer pair 3

Other 3

Microarray probesets 4

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MGI:1289162, MGI:2138434

Summaries

All 74

Developmental Gene Expression 40

Diseases 1

Gene Ontology 7

Phenotypes 10
Earliest

J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
Latest

J:328469 Zhang J, et al., MicroRNA-7a2 is Required for the Development of Pituitary Stem Cells. Stem Cells Dev. 2022 Jul;31(13-14):357-368

TSS for Tbx19:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14758	Chr1:164988358-164988362 (-)	-18 bp
Tssr14757	Chr1:164988343-164988350 (-)	-5 bp
Tssr14756	Chr1:164988241-164988254 (-)	94 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24