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Lpin3 Gene Detail
Summary
  • Symbol
    Lpin3
  • Name
    lipin 3
  • Synonyms
    9130206L11Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891342
    NCBI Gene: 64899
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:160722590-160747920 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 80.98 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    792 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891342
 protein coding gene Chr2:160722590-160747922 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026808
 protein coding gene Chr2:166081381-166107728 (+)
A/J MGP_AJ_G0026774
 protein coding gene Chr2:159408332-159433607 (+)
AKR/J MGP_AKRJ_G0026745
 protein coding gene Chr2:164119468-164144783 (+)
BALB/cJ MGP_BALBcJ_G0026783
 protein coding gene Chr2:159720698-159746990 (+)
C3H/HeJ MGP_C3HHeJ_G0026525
 protein coding gene Chr2:164454382-164481820 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027232
 protein coding gene Chr2:170996277-171021391 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024602
 protein coding gene Chr2:152791538-152808776 (+)
CAST/EiJ MGP_CASTEiJ_G0025987
 protein coding gene Chr2:164835167-164864265 (+)
CBA/J MGP_CBAJ_G0026502
 protein coding gene Chr2:177159172-177186634 (+)
DBA/2J MGP_DBA2J_G0026640
 protein coding gene Chr2:158587854-158612898 (+)
FVB/NJ MGP_FVBNJ_G0026607
 protein coding gene Chr2:156988787-157014263 (+)
LP/J MGP_LPJ_G0026743
 protein coding gene Chr2:166188948-166215070 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026628
 protein coding gene Chr2:180854934-180881242 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027288
 protein coding gene Chr2:163958638-163985914 (+)
PWK/PhJ MGP_PWKPhJ_G0025721
 protein coding gene Chr2:158134689-158160087 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025524
 protein coding gene Chr2:162838357-162863723 (+)
WSB/EiJ MGP_WSBEiJ_G0026057
 protein coding gene Chr2:164853726-164878875 (+)



Homology
more
  • Human Ortholog
    LPIN3, lipin 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LPIN3, lipin 3
  • Synonyms
    dJ620E11.2, LIPN3L, SMP2
  • Links
    NCBI Gene ID: 64900
    neXtProt AC: NX_Q9BQK8
    UniProt: Q9BQK8

  • Chr Location
    20q12; chr20:41340821-41360582 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show slightly decreased body weight, especially with age, and abnormal adipogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    761
  • Tissues
    16
  • cDNA Data
    45
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64899 NCBI Gene Model | MGI Sequence Detail 25331 C57BL/6J ±  kb
    transcript NM_022883 RefSeq | MGI Sequence Detail 3473 C57BL/6  
    polypeptide Q99PI4 UniProt | EBI | MGI Sequence Detail 848 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      cDNA 45
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2139260, MGI:2442081, MGI:3034319
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 13
    • Earliest
      J:66739 Peterfy M, et al., Lipodystrophy in the fld mouse results from mutation of a new gene encoding a nuclear protein, lipin. Nat Genet. 2001 Jan;27(1):121-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory