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Cep41 Gene Detail
Summary
  • Symbol
    Cep41
  • Name
    centrosomal protein 41
  • Synonyms
    1700017E11Rik, 2810431D15Rik, Cep41, Tsga14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891414
    NCBI Gene: 83922
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:30653456-30693748 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.52 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    682 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891414
 protein coding gene Chr6:30653456-30710511 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030543
 protein coding gene Chr6:28555639-28596012 (-)
A/J MGP_AJ_G0030516
 protein coding gene Chr6:27325874-27369190 (-)
AKR/J MGP_AKRJ_G0030443
 protein coding gene Chr6:28240359-28281900 (-)
BALB/cJ MGP_BALBcJ_G0030526
 protein coding gene Chr6:27473658-27514037 (-)
C3H/HeJ MGP_C3HHeJ_G0030239
 protein coding gene Chr6:28231373-28272590 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030980
 protein coding gene Chr6:29358032-29400100 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028191
 protein coding gene Chr6:25517889-25558555 (-)
CAST/EiJ MGP_CASTEiJ_G0029641
 protein coding gene Chr6:28047467-28090613 (-)
CBA/J MGP_CBAJ_G0030217
 protein coding gene Chr6:30486666-30526608 (-)
DBA/2J MGP_DBA2J_G0030361
 protein coding gene Chr6:27256389-27299740 (-)
FVB/NJ MGP_FVBNJ_G0030315
 protein coding gene Chr6:27017387-27061212 (-)
LP/J MGP_LPJ_G0030448
 protein coding gene Chr6:28686176-28726100 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030351
 protein coding gene Chr6:32918827-32958799 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031010
 protein coding gene Chr6:28112801-28154420 (-)
PWK/PhJ MGP_PWKPhJ_G0029355
 protein coding gene Chr6:26831360-26872478 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029191
 protein coding gene Chr6:27857652-27902193 (-)
WSB/EiJ MGP_WSBEiJ_G0029717
 protein coding gene Chr6:28084151-28125873 (-)



Homology
more
  • Human Ortholog
    CEP41, centrosomal protein 41
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEP41, centrosomal protein 41
  • Synonyms
    JBTS15, TSGA14
  • Links
    NCBI Gene ID: 95681
    neXtProt AC: NX_Q9BYV8
    UniProt: Q9BYV8

  • Chr Location
    7q32.2; chr7:130393771-130442433 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CEP41 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous disruption of this gene causes an abnormal gait, increased thermal nociceptive threshold, and alterations in fertility/fecundity and eye morphology. Some embryos homozygous for a gene trapped allele die at E10-E12 exhibiting turning failure, dilated pericardial sacs, and brain anomalies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    728
  • Tissues
    1
  • cDNA Data
    43
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029790 Ensembl Gene Model | MGI Sequence Detail 40293 C57BL/6J ±  kb
    transcript ENSMUST00000031810 Ensembl | MGI Sequence Detail 3447 Not Applicable  
    polypeptide ENSMUSP00000031810 Ensembl | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1889830, MGI:1916627, MGI:1925624, MGI:2141435
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:61896 Lee YJ, et al., Mit1/Lb9 and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest(1). FEBS Lett. 2000 Apr 28;472(2-3):230-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory