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Pde4dip Gene Detail
Summary
  • Symbol
    Pde4dip
  • Name
    phosphodiesterase 4D interacting protein (myomegalin)
  • Synonyms
    4732458A06Rik, 9430063L05Rik, D130016K21Rik, D3Bwg1078e, mKIAA0454, Usmg4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891434
    NCBI Gene: 83679
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:97597144-97796023 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 42.28 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5982 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891434
 protein coding gene Chr3:97597140-97796023 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027645
 protein coding gene Chr3:98644544-98860995 (-)
A/J MGP_AJ_G0027607
 protein coding gene Chr3:95489617-95691205 (-)
AKR/J MGP_AKRJ_G0027574
 protein coding gene Chr3:97775008-97984603 (-)
BALB/cJ MGP_BALBcJ_G0027617
 protein coding gene Chr3:95290741-95494903 (-)
C3H/HeJ MGP_C3HHeJ_G0027349
 protein coding gene Chr3:98043567-98255291 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028063
 protein coding gene Chr3:102319012-102534365 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025405
 protein coding gene Chr3:91749083-91948031 (-)
CAST/EiJ MGP_CASTEiJ_G0026804
 protein coding gene Chr3:97338097-97549113 (-)
CBA/J MGP_CBAJ_G0027324
 protein coding gene Chr3:105956744-106187798 (-)
DBA/2J MGP_DBA2J_G0027467
 protein coding gene Chr3:94803413-95003558 (-)
FVB/NJ MGP_FVBNJ_G0027436
 protein coding gene Chr3:92792971-92996672 (-)
LP/J MGP_LPJ_G0027572
 protein coding gene Chr3:99905623-100118928 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027462
 protein coding gene Chr3:112052367-112269799 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028117
 protein coding gene Chr3:97398571-97609775 (-)
PWK/PhJ MGP_PWKPhJ_G0026529
 protein coding gene Chr3:94669568-94891028 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026351
 protein coding gene Chr3:95674139-95887768 (-)
WSB/EiJ MGP_WSBEiJ_G0026882
 protein coding gene Chr3:97834059-98047923 (-)



Homology
more
  • Human Ortholog
    PDE4DIP, phosphodiesterase 4D interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE4DIP, phosphodiesterase 4D interacting protein
  • Synonyms
    CMYA2, MMGL
  • Links
    NCBI Gene ID: 9659
    neXtProt AC: NX_Q5VU43
    UniProt: Q5VU43

  • Chr Location
    1q21.2; chr1:148808140-149048286 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit partial (in utero or perinatal) lethality, hyperactivity, and increased vertical activity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    908
  • Tissues
    164
  • cDNA Data
    175
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 83679 NCBI Gene Model | MGI Sequence Detail 198880 C57BL/6J ±  kb
    transcript NM_001039376 RefSeq | MGI Sequence Detail 8420 ZRU/MplStud  
    polypeptide Q80YT7 UniProt | EBI | MGI Sequence Detail 2224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR042791 CDK5 regulatory subunit-associated protein 2
      IPR012943 Centrosomin, N-terminal motif 1
      IPR052593 Microtubule-associated AKAP9-binding protein
      IPR010630 Olduvai domain
      IPR040947 Short myomegalin-like EB1 binding protein, N-terminal
      IPR012934 Zinc finger, AD-type
    • GlyGen
      Q80YT7 3 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 182
      cDNA 178
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-34220, MGI:106526, MGI:1924553, MGI:2140100, MGI:2442981, MGI:2443905
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory