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Peli2 Gene Detail
Summary
  • Symbol
    Peli2
  • Name
    pellino 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891445
    NCBI Gene: 93834
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:48358280-48519032 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 24.60 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4852 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891445
 protein coding gene Chr14:48358096-48519035 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021225
 protein coding gene Chr14:41940361-42089016 (+)
A/J MGP_AJ_G0021174
 protein coding gene Chr14:40648106-40787029 (+)
AKR/J MGP_AKRJ_G0021152
 protein coding gene Chr14:42229102-42372021 (+)
BALB/cJ MGP_BALBcJ_G0021177
 protein coding gene Chr14:40696435-40838121 (+)
C3H/HeJ MGP_C3HHeJ_G0020960
 protein coding gene Chr14:42017148-42164912 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021612
 protein coding gene Chr14:43686031-43834597 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019171
 protein coding gene Chr14:39982667-40123531 (+)
CAST/EiJ MGP_CASTEiJ_G0020486
 protein coding gene Chr14:39143679-39293936 (+)
CBA/J MGP_CBAJ_G0020927
 protein coding gene Chr14:45108136-45258528 (+)
DBA/2J MGP_DBA2J_G0021050
 protein coding gene Chr14:40531642-40671374 (+)
FVB/NJ MGP_FVBNJ_G0021035
 protein coding gene Chr14:40272077-40412327 (+)
LP/J MGP_LPJ_G0021119
 protein coding gene Chr14:42193697-42340638 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021060
 protein coding gene Chr14:44427825-44570825 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021645
 protein coding gene Chr14:41766700-41909948 (+)
PWK/PhJ MGP_PWKPhJ_G0020234
 protein coding gene Chr14:37412810-37554888 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020059
 protein coding gene Chr14:37903868-38048533 (+)
WSB/EiJ MGP_WSBEiJ_G0020542
 protein coding gene Chr14:41871241-42015398 (+)



Homology
more
  • Human Ortholog
    PELI2, pellino E3 ubiquitin protein ligase family member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PELI2, pellino E3 ubiquitin protein ligase family member 2
  • Links
    NCBI Gene ID: 57161
    neXtProt AC: NX_Q9HAT8
    UniProt: Q9HAT8

  • Chr Location
    14q22.3; chr14:56117814-56301524 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout reduces the immune response to gram-negative bacteria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    924
  • Tissues
    39
  • cDNA Data
    9
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021846 Ensembl Gene Model | MGI Sequence Detail 160753 C57BL/6J ±  kb
    transcript ENSMUST00000247875 Ensembl | MGI Sequence Detail 5900 Not Applicable  
    polypeptide ENSMUSP00000159539 Ensembl | MGI Sequence Detail 472 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 11
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145788, MGI:2145853
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:68867 Resch K, et al., Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. Cytogenet Cell Genet. 2001;92(1-2):172-4
    • Latest
      J:342723 Oleszycka E, et al., Dendritic Cell-Specific Role for Pellino2 as a Mediator of TLR9 Signaling Pathway. J Immunol. 2021 Nov 1;207(9):2325-2336
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory