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Dact1 Gene Detail
Summary
  • Symbol
    Dact1
  • Name
    dishevelled-binding antagonist of beta-catenin 1
  • Synonyms
    Dapper1, Frd1, Frodo, Frodo1, THYEX3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891740
    NCBI Gene: 59036
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:71356658-71366881 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 29.39 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    317 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891740
 protein coding gene Chr12:71356658-71366881 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019818
 protein coding gene Chr12:71090741-71103090 (+)
A/J MGP_AJ_G0019776
 protein coding gene Chr12:68439493-68449758 (+)
AKR/J MGP_AKRJ_G0019752
 protein coding gene Chr12:70498433-70508700 (+)
BALB/cJ MGP_BALBcJ_G0019756
 protein coding gene Chr12:68912245-68922495 (+)
C3H/HeJ MGP_C3HHeJ_G0019561
 protein coding gene Chr12:70968164-70978410 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020208
 protein coding gene Chr12:73346920-73358735 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017828
 protein coding gene Chr12:65936162-65946352 (+)
CAST/EiJ MGP_CASTEiJ_G0019113
 protein coding gene Chr12:65704125-65715046 (+)
CBA/J MGP_CBAJ_G0019531
 protein coding gene Chr12:76084512-76094737 (+)
DBA/2J MGP_DBA2J_G0019647
 protein coding gene Chr12:68348295-68358507 (+)
FVB/NJ MGP_FVBNJ_G0019634
 protein coding gene Chr12:67223797-67234117 (+)
LP/J MGP_LPJ_G0019719
 protein coding gene Chr12:71091997-71102265 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019673
 protein coding gene Chr12:79295558-79305830 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020243
 protein coding gene Chr12:69976678-69987288 (+)
PWK/PhJ MGP_PWKPhJ_G0018878
 protein coding gene Chr12:62627402-62638024 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018673
 protein coding gene Chr12:64354277-64365519 (+)
WSB/EiJ MGP_WSBEiJ_G0019164
 protein coding gene Chr12:70592546-70603281 (+)



Homology
more
  • Human Ortholog
    DACT1, dishevelled binding antagonist of beta catenin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DACT1, dishevelled binding antagonist of beta catenin 1
  • Synonyms
    DAPPER, DAPPER1, DPR1, FRODO, HDPR1, TBS2, THYEX3
  • Links
    NCBI Gene ID: 51339
    neXtProt AC: NX_Q9NYF0
    UniProt: Q9NYF0

  • Chr Location
    14q23.1; chr14:58633967-58648321 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DACT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    59 phenotypes from 3 alleles in 4 genetic backgrounds
    11 phenotypes from multigenic genotypes
    2 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit neonatal lethality, abnormal embryogenesis, blind-ended colons, and abnormal renal/urinary system.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1322
  • Tissues
    282
  • cDNA Data
    12
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 59036 NCBI Gene Model | MGI Sequence Detail 10224 C57BL/6J ±  kb
    transcript NM_001190466 RefSeq | MGI Sequence Detail 3761 C57BL/6  
    polypeptide Q8R4A3 UniProt | EBI | MGI Sequence Detail 778 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 14
      Primer pair 2
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1913988, MGI:2144761
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 23
      Gene Ontology 15
      Phenotypes 14
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory