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Pfkp Gene Detail
Summary
  • Symbol
    Pfkp
  • Name
    phosphofructokinase, platelet
  • Synonyms
    1200015H23Rik, 9330125N24Rik, PFK-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891833
    NCBI Gene: 56421
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:6629804-6698813 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 3.25 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2162 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1891833
 protein coding gene Chr13:6629804-6699096 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020215
 protein coding gene Chr13:3153902-3221366 (-)
A/J MGP_AJ_G0020171
 protein coding gene Chr13:3183018-3250030 (-)
AKR/J MGP_AKRJ_G0020146
 protein coding gene Chr13:3258520-3322849 (-)
BALB/cJ MGP_BALBcJ_G0020154
 protein coding gene Chr13:3173965-3239609 (-)
C3H/HeJ MGP_C3HHeJ_G0019958
 protein coding gene Chr13:3342803-3405524 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020601
 protein coding gene Chr13:3345572-3409362 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018211
 protein coding gene Chr13:3078777-3142647 (-)
CAST/EiJ MGP_CASTEiJ_G0019498
 protein coding gene Chr13:3133902-3197134 (-)
CBA/J MGP_CBAJ_G0019925
 protein coding gene Chr13:3411244-3476460 (-)
DBA/2J MGP_DBA2J_G0020042
 protein coding gene Chr13:3092954-3155051 (-)
FVB/NJ MGP_FVBNJ_G0020027
 protein coding gene Chr13:2970210-3039908 (-)
LP/J MGP_LPJ_G0020116
 protein coding gene Chr13:3302065-3373213 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020063
 protein coding gene Chr13:3648756-3719621 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020629
 protein coding gene Chr13:3210826-3275142 (-)
PWK/PhJ MGP_PWKPhJ_G0019258
 protein coding gene Chr13:2952391-3188024 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019066
 protein coding gene Chr13:3277682-3345419 (-)
WSB/EiJ MGP_WSBEiJ_G0019556
 protein coding gene Chr13:3143717-3207083 (-)



Homology
more
  • Human Ortholog
    PFKP, phosphofructokinase, platelet
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PFKP, phosphofructokinase, platelet
  • Synonyms
    ATP-PFK, PFK-C, PFKF, PFK-P
  • Links
    NCBI Gene ID: 5214
    neXtProt AC: NX_Q01813
    UniProt: Q01813

  • Chr Location
    10p15.2; chr10:3066333-3137718 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1295
  • Tissues
    160
  • cDNA Data
    25
  • Literature Summary
    21
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021196 Ensembl Gene Model | MGI Sequence Detail 69010 C57BL/6J ±  kb
transcript ENSMUST00000138703 Ensembl | MGI Sequence Detail 4145 Not Applicable  
polypeptide ENSMUSP00000117030 Ensembl | MGI Sequence Detail 784 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000012584 ATP-dependent 6-phosphofructokinase, platelet type
    (term hierarchy)
  • EC
    2.7.1.11
  • InterPro Domains
    IPR022953 ATP-dependent 6-phosphofructokinase
    IPR009161 ATP-dependent 6-phosphofructokinase, eukaryotic-type
    IPR041914 ATP-dependent 6-phosphofructokinase, vertebrate-type
    IPR015912 Phosphofructokinase, conserved site
    IPR000023 Phosphofructokinase domain
    IPR035966 Phosphofructokinase superfamily
  • GlyGen
    Q9WUA3 2 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 29
    cDNA 25
    Primer pair 4

    Microarray probesets 7
Other
Accession IDs
less
MGI:1921374, MGI:1924805
References
more
  • Summaries
    All 66
    Developmental Gene Expression 21
    Gene Ontology 10
    Phenotypes 11
  • Earliest
    J:139710 Gekakis N, et al., Phosphofructokinase isozyme expression during myoblast differentiation. J Biol Chem. 1989 Mar 5;264(7):3658-61
  • Latest
    J:344840 Cao L, et al., Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells. EMBO Rep. 2023 Mar 6;24(3):e55683
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory