About   Help   FAQ
Cldn15 Gene Detail
Summary
  • Symbol
    Cldn15
  • Name
    claudin 15
  • Synonyms
    2210009B08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913103
    NCBI Gene: 60363
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136996723-137004699 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 76.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    356 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913103
 protein coding gene Chr5:136995470-137004712 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030211
 protein coding gene Chr5:141668404-141678989 (+)
A/J MGP_AJ_G0030179
 protein coding gene Chr5:135537422-135548499 (+)
AKR/J MGP_AKRJ_G0030112
 protein coding gene Chr5:139929263-139938415 (+)
BALB/cJ MGP_BALBcJ_G0030189
 protein coding gene Chr5:136898550-136907690 (+)
C3H/HeJ MGP_C3HHeJ_G0029905
 protein coding gene Chr5:140549999-140560107 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030641
 protein coding gene Chr5:146947385-146956423 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0029315
 protein coding gene Chr5:139966221-139978246 (+)
CBA/J MGP_CBAJ_G0029875
 protein coding gene Chr5:152676072-152689457 (+)
DBA/2J MGP_DBA2J_G0030026
 protein coding gene Chr5:135432360-135441607 (+)
FVB/NJ MGP_FVBNJ_G0029981
 protein coding gene Chr5:134610586-134620195 (+)
LP/J MGP_LPJ_G0030115
 protein coding gene Chr5:142108316-142119142 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030013
 protein coding gene Chr5:155583828-155594157 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030682
 protein coding gene Chr5:139754256-139765501 (+)
PWK/PhJ MGP_PWKPhJ_G0029028
 protein coding gene Chr5:134520636-134530239 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028864
 protein coding gene Chr5:137346241-137355229 (+)
WSB/EiJ MGP_WSBEiJ_G0029388
 protein coding gene Chr5:140500823-140509979 (+)



Homology
more
  • Human Ortholog
    CLDN15, claudin 15
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLDN15, claudin 15
  • Links
    NCBI Gene ID: 24146
    neXtProt AC: NX_P56746
    UniProt: P56746

  • Chr Location
    7q22.1; chr7:101232092-101238820 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable and grow normally with an enlarged upper small intestinal phenotype (megaintestine) resulting from enhanced proliferation of normal cryptic cells after weaning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    7
  • cDNA Data
    29
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 60363 NCBI Gene Model | MGI Sequence Detail 7977 C57BL/6J ±  kb
    transcript NM_021719 RefSeq | MGI Sequence Detail 1878 C57BL/6  
    polypeptide Q9Z0S5 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      cDNA 29
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914340, MGI:2141263
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 8
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:64941 Morita K, et al., Claudin-11/OSP-based tight junctions of myelin sheaths in brain and Sertoli cells in testis. J Cell Biol. 1999 May 3;145(3):579-88
    • Latest
      J:351645 Audiger C, et al., Mis-expression of GATA6 re-programs cell fate during early hematopoiesis. Cell Rep. 2024 May 28;43(5):114159
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory