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Cep20 Gene Detail
Summary
  • Symbol
    Cep20
  • Name
    centrosomal protein 20
  • Synonyms
    0610037P05Rik, Fopnl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913336
    NCBI Gene: 66086
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:14117108-14135269 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 9.74 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    589 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913336
 protein coding gene Chr16:14117105-14136093 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022544
 protein coding gene Chr16:11351581-11369776 (-)
A/J MGP_AJ_G0022506
 protein coding gene Chr16:10710319-10728071 (-)
AKR/J MGP_AKRJ_G0022482
 protein coding gene Chr16:11179271-11198149 (-)
BALB/cJ MGP_BALBcJ_G0022510
 protein coding gene Chr16:10886811-10904859 (-)
C3H/HeJ MGP_C3HHeJ_G0022277
 protein coding gene Chr16:11282271-11300512 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022959
 protein coding gene Chr16:11500012-11517713 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020479
 protein coding gene Chr16:10803978-10821501 (-)
CAST/EiJ MGP_CASTEiJ_G0021804
 protein coding gene Chr16:11309020-11327594 (-)
CBA/J MGP_CBAJ_G0022246
 protein coding gene Chr16:12053227-12071039 (-)
DBA/2J MGP_DBA2J_G0022377
 protein coding gene Chr16:10711050-10728867 (-)
FVB/NJ MGP_FVBNJ_G0022353
 protein coding gene Chr16:10693034-10710950 (-)
LP/J MGP_LPJ_G0022445
 protein coding gene Chr16:11238824-11257998 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022375
 protein coding gene Chr16:11672063-11691652 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022972
 protein coding gene Chr16:11156996-11174754 (-)
PWK/PhJ MGP_PWKPhJ_G0021546
 protein coding gene Chr16:10969578-10987594 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021375
 protein coding gene Chr16:11146000-11163470 (-)
WSB/EiJ MGP_WSBEiJ_G0021852
 protein coding gene Chr16:11170070-11187698 (-)



Homology
more
  • Human Ortholog
    CEP20, centrosomal protein 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEP20, centrosomal protein 20
  • Synonyms
    C16orf63, FOPNL, FOR20, PHSECRG2
  • Links
    NCBI Gene ID: 123811
    neXtProt AC: NX_Q96NB1
    UniProt: Q96NB1

  • Chr Location
    16p13.11; chr16:15865719-15888625 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knock-out results in embryonic growth arrest and lethality around E10.5 to E11.5, impaired left-right pattering with failed body turning and disorganized heart looping, defective angiogenesis, and disrupted nodal ciliogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    19
  • cDNA Data
    77
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022677 Ensembl Gene Model | MGI Sequence Detail 18162 C57BL/6J ±  kb
    transcript ENSMUST00000023357 Ensembl | MGI Sequence Detail 1465 Not Applicable  
    polypeptide ENSMUSP00000023357 Ensembl | MGI Sequence Detail 174 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 78
      cDNA 77
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:6391259
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 8
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:308526 Xu Z, et al., Centrosomal protein FOR20 knockout mice display embryonic lethality and left-right patterning defects. FEBS Lett. 2021 May;595(10):1462-1472
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    12/10/2024
    MGI 6.24     		The Jackson Laboratory