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Eif1ax Gene Detail
Summary
  • Symbol
    Eif1ax
  • Name
    eukaryotic translation initiation factor 1A, X-linked
  • Synonyms
    1500010B24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913485
    NCBI Gene: 66235
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:158155174-158172617 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 73.41 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    482 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913485
 protein coding gene ChrX:158155174-158172924 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036224
 protein coding gene ChrX:157266759-157285633 (+)
A/J MGP_AJ_G0036194
 protein coding gene ChrX:156553842-156571904 (+)
AKR/J MGP_AKRJ_G0036122
 protein coding gene ChrX:161519539-161541101 (+)
BALB/cJ MGP_BALBcJ_G0036187
 protein coding gene ChrX:154627288-154647175 (+)
C3H/HeJ MGP_C3HHeJ_G0035893
 protein coding gene ChrX:157661129-157679811 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036709
 protein coding gene ChrX:161954892-161975404 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033531
 protein coding gene ChrX:147835710-147853377 (+)
CAST/EiJ MGP_CASTEiJ_G0035182
 protein coding gene ChrX:136702373-136723654 (+)
CBA/J MGP_CBAJ_G0035868
 protein coding gene ChrX:166565846-166583738 (+)
DBA/2J MGP_DBA2J_G0036034
 protein coding gene ChrX:155535837-155556957 (+)
FVB/NJ MGP_FVBNJ_G0035965
 protein coding gene ChrX:154657456-154675162 (+)
LP/J MGP_LPJ_G0036119
 protein coding gene ChrX:158433315-158451596 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035997
 protein coding gene ChrX:175261297-175280284 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036750
 protein coding gene ChrX:156812262-156832998 (+)
PWK/PhJ MGP_PWKPhJ_G0034880
 protein coding gene ChrX:133586532-133604858 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034701
 protein coding gene ChrX:137129813-137147787 (+)
WSB/EiJ MGP_WSBEiJ_G0035317
 protein coding gene ChrX:154779249-154796906 (+)



Homology
more
  • Human Ortholog
    EIF1AX, eukaryotic translation initiation factor 1A X-linked
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF1AX, eukaryotic translation initiation factor 1A X-linked
  • Synonyms
    eIF-1A, EIF1A, EIF1AP1, eIF-4C, EIF4C
  • Links
    NCBI Gene ID: 1964
    neXtProt AC: NX_P47813
    UniProt: P47813

  • Chr Location
    Xp22.12; chrX:20124525-20141838 (-)  GRCh38
  • Human Ortholog
    EIF1AY, eukaryotic translation initiation factor 1A Y-linked
  • Synonyms
    eIF-4C
  • Links
    NCBI Gene ID: 9086
    neXtProt AC: NX_O14602
    UniProt: O14602

  • Chr Location
    Yq11.223; chrY:20575776-20593154 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    17
  • Endonuclease-mediated
    2
  • Gene trapped
    12
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Eif1ax
  • Find Mice (IMSR)
    13 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    25
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 66235 NCBI Gene Model | MGI Sequence Detail 17444 C57BL/6J ±  kb
transcript NM_025437 RefSeq | MGI Sequence Detail 4865 C57BL/6  
polypeptide Q8BMJ3 UniProt | EBI | MGI Sequence Detail 144 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR012340 Nucleic acid-binding, OB-fold
    IPR006196 RNA-binding domain, S1, IF1 type
    IPR001253 Translation initiation factor 1A (eIF-1A)
    IPR018104 Translation initiation factor 1A (eIF-1A), conserved site
Molecular
Reagents
less
  • All nucleic 26
    cDNA 25
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
less
MGI:2147882
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:46359 Blair HJ, et al., Mouse mutants carrying deletions that remove the genes mutated in Coffin-Lowry syndrome and lactic acidosis. Hum Mol Genet. 1998 Mar;7(3):549-55
  • Latest
    J:313842 Mattebo A, et al., Yippee like 4 (Ypel4) is essential for normal mouse red blood cell membrane integrity. Sci Rep. 2021 Aug 5;11(1):15898
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory