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Hspbp1 Gene Detail
Summary
  • Symbol
    Hspbp1
  • Name
    HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
  • Synonyms
    1500019G21Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913495
    NCBI Gene: 66245
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4663520-4688067 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 2.69 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    747 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913495
 protein coding gene Chr7:4663514-4688218 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031554
 protein coding gene Chr7:1578009-1608070 (-)
A/J MGP_AJ_G0031528
 protein coding gene Chr7:1592203-1615887 (-)
AKR/J MGP_AKRJ_G0031457
 protein coding gene Chr7:1652790-1684050 (-)
BALB/cJ MGP_BALBcJ_G0031536
 protein coding gene Chr7:1634228-1660570 (-)
C3H/HeJ MGP_C3HHeJ_G0031257
 protein coding gene Chr7:1630949-1657956 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031997
 protein coding gene Chr7:1638731-1667051 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029121
 protein coding gene Chr7:1345532-1367916 (-)
CAST/EiJ MGP_CASTEiJ_G0030621
 protein coding gene Chr7:1568839-1593803 (-)
CBA/J MGP_CBAJ_G0031215
 protein coding gene Chr7:1830724-1859117 (-)
DBA/2J MGP_DBA2J_G0031374
 protein coding gene Chr7:1574562-1599275 (-)
FVB/NJ MGP_FVBNJ_G0031326
 protein coding gene Chr7:1538070-1564398 (-)
LP/J MGP_LPJ_G0031459
 protein coding gene Chr7:1693331-1719464 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031365
 protein coding gene Chr7:1767006-1803731 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032027
 protein coding gene Chr7:1566833-1595080 (-)
PWK/PhJ MGP_PWKPhJ_G0030349
 protein coding gene Chr7:1740907-1765531 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030174
 protein coding gene Chr7:1620376-1643544 (-)
WSB/EiJ MGP_WSBEiJ_G0030716
 protein coding gene Chr7:1582478-1610394 (-)



Homology
more
  • Human Ortholog
    HSPBP1, HSPA (Hsp70) binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPBP1, HSPA (Hsp70) binding protein 1
  • Synonyms
    FES1
  • Links
    NCBI Gene ID: 23640
    neXtProt AC: NX_Q9NZL4
    UniProt: Q9NZL4

  • Chr Location
    19q13.42; chr19:55262223-55280383 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation show male infertility with an arrest of male meiosis, increased male germ cell apoptosis and azoospermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    96
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000063802 Ensembl Gene Model | MGI Sequence Detail 24548 C57BL/6J ±  kb
    transcript ENSMUST00000079970 Ensembl | MGI Sequence Detail 1593 Not Applicable  
    polypeptide ENSMUSP00000078886 Ensembl | MGI Sequence Detail 357 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      cDNA 96

      Microarray probesets 4
    References
    more
    • Summaries
      All 32
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:253642 Zhao T, et al., Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins. Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7803-E7811
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory