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Smim20 Gene Detail
Summary
  • Symbol
    Smim20
  • Name
    small integral membrane protein 20
  • Synonyms
    1110067B18Rik, 1810013D10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913528
    NCBI Gene: 66278
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:53424448-53435882 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 29.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    392 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913528
 protein coding gene Chr5:53424425-53435882 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029553
 protein coding gene Chr5:52298786-52310238 (+)
A/J MGP_AJ_G0029521
 protein coding gene Chr5:50460380-50471997 (+)
AKR/J MGP_AKRJ_G0029469
 protein coding gene Chr5:52197796-52209304 (+)
BALB/cJ MGP_BALBcJ_G0029530
 protein coding gene Chr5:50949064-50960236 (+)
C3H/HeJ MGP_C3HHeJ_G0029253
 protein coding gene Chr5:52336500-52351942 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029984
 protein coding gene Chr5:54459871-54471201 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027224
 protein coding gene Chr5:47215642-47226826 (+)
CAST/EiJ MGP_CASTEiJ_G0028661
 protein coding gene Chr5:51345010-51358075 (+)
CBA/J MGP_CBAJ_G0029222
 protein coding gene Chr5:56137586-56149047 (+)
DBA/2J MGP_DBA2J_G0029368
 protein coding gene Chr5:50524491-50536708 (+)
FVB/NJ MGP_FVBNJ_G0029328
 protein coding gene Chr5:49861415-49874113 (+)
LP/J MGP_LPJ_G0029453
 protein coding gene Chr5:52763909-52775366 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029356
 protein coding gene Chr5:57208126-57219581 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030017
 protein coding gene Chr5:51673409-51685673 (+)
PWK/PhJ MGP_PWKPhJ_G0028385
 protein coding gene Chr5:49585740-49598207 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028219
 protein coding gene Chr5:51115071-51128665 (+)
WSB/EiJ MGP_WSBEiJ_G0028742
 protein coding gene Chr5:51730881-51744158 (+)



Homology
more
  • Human Ortholog
    SMIM20, small integral membrane protein 20
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMIM20, small integral membrane protein 20
  • Synonyms
    C4orf52, MITRAC7, PNX
  • Links
    NCBI Gene ID: 389203
    neXtProt AC: NX_Q8N5G0
    UniProt: Q8N5G0

  • Chr Location
    4p15.2; chr4:25861830-25929813 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for knock-out allele exhibit normal fertility and have no major alterations in their metabolic response to a high-fat diet but show altered behavior in an open field test.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    5
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66278 NCBI Gene Model | MGI Sequence Detail 11435 C57BL/6J ±  kb
    transcript NM_001145433 RefSeq | MGI Sequence Detail 1036 C57BL/6  
    polypeptide D3Z7Q2 UniProt | EBI | MGI Sequence Detail 69 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      Genomic 2
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1919046, MGI:2141348
    References
    more
    • Summaries
      All 44
      Gene Ontology 3
      Phenotypes 23
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:350521 McIlwraith EK, et al., Phoenixin knockout mice show no impairment in fertility or differences in metabolic response to a high-fat diet, but exhibit behavioral differences in an open field test. J Neuroendocrinol. 2024 May 10;:e13398
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/02/2024
    MGI 6.24     		The Jackson Laboratory