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Farsa Gene Detail
Summary
  • Symbol
    Farsa
  • Name
    phenylalanyl-tRNA synthetase, alpha subunit
  • Synonyms
    0610012A19Rik, Farsla
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913840
    NCBI Gene: 66590
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85583618-85595886 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.23 cM, cytoband C3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    285 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913840
 protein coding gene Chr8:85583597-85595886 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033875
 protein coding gene Chr8:85782646-85794733 (+)
A/J MGP_AJ_G0033858
 protein coding gene Chr8:82402695-82414559 (+)
AKR/J MGP_AKRJ_G0033784
 protein coding gene Chr8:84841486-84855355 (+)
BALB/cJ MGP_BALBcJ_G0033851
 protein coding gene Chr8:82527393-82540980 (+)
C3H/HeJ MGP_C3HHeJ_G0033561
 protein coding gene Chr8:85466442-85478461 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034371
 protein coding gene Chr8:89062426-89074678 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031312
 protein coding gene Chr8:76194161-76207306 (+)
CAST/EiJ MGP_CASTEiJ_G0032891
 protein coding gene Chr8:84888595-84902498 (+)
CBA/J MGP_CBAJ_G0033537
 protein coding gene Chr8:92103729-92115784 (+)
DBA/2J MGP_DBA2J_G0033690
 protein coding gene Chr8:82041442-82053532 (+)
FVB/NJ MGP_FVBNJ_G0033638
 protein coding gene Chr8:80985494-80997595 (+)
LP/J MGP_LPJ_G0033782
 protein coding gene Chr8:85889295-85901394 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033680
 protein coding gene Chr8:94659442-94671515 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034388
 protein coding gene Chr8:84831736-84844773 (+)
PWK/PhJ MGP_PWKPhJ_G0032595
 protein coding gene Chr8:81287846-81300349 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032431
 protein coding gene Chr8:83637553-83649611 (+)
WSB/EiJ MGP_WSBEiJ_G0033004
 protein coding gene Chr8:85257958-85269954 (+)



Homology
more
  • Human Ortholog
    FARSA, phenylalanyl-tRNA synthetase subunit alpha
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FARSA, phenylalanyl-tRNA synthetase subunit alpha
  • Synonyms
    CML33, FARSL, FARSLA, FRSA, PheHA, RILDBC2
  • Links
    NCBI Gene ID: 2193
    neXtProt AC: NX_Q9Y285
    UniProt: Q9Y285

  • Chr Location
    19p13.13; chr19:12922479-12934037 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    102
  • cDNA Data
    119
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003808 Ensembl Gene Model | MGI Sequence Detail 12269 C57BL/6J ±  kb
    transcript ENSMUST00000003906 Ensembl | MGI Sequence Detail 1826 Not Applicable  
    polypeptide ENSMUSP00000003906 Ensembl | MGI Sequence Detail 508 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      7 Sequences
    • Protein Ontology
      PR:000007346 eukaryotic-type phenylalanine--tRNA ligase alpha subunit
      (term hierarchy)
    • EC
      6.1.1.20
    • InterPro Domains
      IPR006195 Aminoacyl-tRNA synthetase, class II
      IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
      IPR002319 Phenylalanyl-tRNA synthetase
      IPR004529 Phenylalanyl-tRNA synthetase, class IIc, alpha subunit
      IPR040724 PheRS, DNA binding domain 1
      IPR040586 PheRS DNA binding domain 2
      IPR040725 PheRS, DNA binding domain 3
      IPR036390 Winged helix DNA-binding domain superfamily
    • GlyGen
      Q8C0C7 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 119
      cDNA 119

      Microarray probesets 5
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 44
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory