About   Help   FAQ
Diablo Gene Detail
Summary
  • Symbol
    Diablo
  • Name
    diablo, IAP-binding mitochondrial protein
  • Synonyms
    0610041G12Rik, 1700006L01Rik, Smac
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913843
    NCBI Gene: 66593
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123647828-123662239 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.02 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    322 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913843
 protein coding gene Chr5:123647828-123664825 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030074
 protein coding gene Chr5:127250652-127264398 (-)
A/J MGP_AJ_G0030039
 protein coding gene Chr5:121975595-121989341 (-)
AKR/J MGP_AKRJ_G0029975
 protein coding gene Chr5:125915792-125929448 (-)
BALB/cJ MGP_BALBcJ_G0030050
 protein coding gene Chr5:123308789-123322535 (-)
C3H/HeJ MGP_C3HHeJ_G0029766
 protein coding gene Chr5:126522067-126537753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030503
 protein coding gene Chr5:132185195-132200384 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027728
 protein coding gene Chr5:116521159-116536470 (-)
CAST/EiJ MGP_CASTEiJ_G0029176
 protein coding gene Chr5:125620617-125634221 (-)
CBA/J MGP_CBAJ_G0029737
 protein coding gene Chr5:137381556-137395292 (-)
DBA/2J MGP_DBA2J_G0029886
 protein coding gene Chr5:121991940-122007627 (-)
FVB/NJ MGP_FVBNJ_G0029843
 protein coding gene Chr5:121021411-121035154 (-)
LP/J MGP_LPJ_G0029976
 protein coding gene Chr5:127793894-127807640 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029874
 protein coding gene Chr5:141017708-141031444 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030544
 protein coding gene Chr5:125499775-125514342 (-)
PWK/PhJ MGP_PWKPhJ_G0028890
 protein coding gene Chr5:120799573-120813398 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028726
 protein coding gene Chr5:123178150-123194034 (-)
WSB/EiJ MGP_WSBEiJ_G0029251
 protein coding gene Chr5:126172441-126186184 (-)



Homology
more
  • Human Ortholog
    DIABLO, diablo IAP-binding mitochondrial protein
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DIABLO, diablo IAP-binding mitochondrial protein
  • Synonyms
    DFNA64, SMAC
  • Links
    NCBI Gene ID: 56616
    neXtProt AC: NX_Q9NR28
    UniProt: Q9NR28

  • Chr Location
    12q24.31; chr12:122207662-122227456 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DIABLO associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    19 phenotype references
Homozygotes are viable and fertile with no gross morphological or histological abnormalities. Normal induction of apoptosis in UV-irradiated or Fas-antibody treated cells was noted, and these mice also exhibit normal T and B cell proliferative responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    770
  • Tissues
    21
  • cDNA Data
    101
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029433 Ensembl Gene Model | MGI Sequence Detail 14412 C57BL/6J ±  kb
transcript ENSMUST00000125652 Ensembl | MGI Sequence Detail 3386 Not Applicable  
polypeptide ENSMUSP00000115045 Ensembl | MGI Sequence Detail 237 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 103
    cDNA 101
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923950, MGI:2141076
References
more
  • Summaries
    All 70
    Developmental Gene Expression 8
    Gene Ontology 16
    Phenotypes 19
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:314103 Ulmke PA, et al., Molecular Profiling Reveals Involvement of ESCO2 in Intermediate Progenitor Cell Maintenance in the Developing Mouse Cortex. Stem Cell Reports. 2021 Apr 13;16(4):968-984
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory