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Pigk Gene Detail
Summary
  • Symbol
    Pigk
  • Name
    phosphatidylinositol glycan anchor biosynthesis, class K
  • Synonyms
    3000001O05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913863
    NCBI Gene: 329777
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:152419718-152548705 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 77.16 cM, cytoband H4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3777 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913863
 protein coding gene Chr3:152419718-152686045 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027994
 protein coding gene Chr3:156602948-156879700 (+)
A/J MGP_AJ_G0027953
 protein coding gene Chr3:150913411-151180286 (+)
AKR/J MGP_AKRJ_G0027919
 protein coding gene Chr3:154914998-155192723 (+)
BALB/cJ MGP_BALBcJ_G0027965
 protein coding gene Chr3:150730127-150992580 (+)
C3H/HeJ MGP_C3HHeJ_G0027695
 protein coding gene Chr3:155318296-155601083 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028408
 protein coding gene Chr3:161742202-162018516 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025746
 protein coding gene Chr3:145718650-145987400 (+)
CAST/EiJ MGP_CASTEiJ_G0027148
 protein coding gene Chr3:155405180-155685895 (+)
CBA/J MGP_CBAJ_G0027670
 protein coding gene Chr3:167560492-167843235 (+)
DBA/2J MGP_DBA2J_G0027810
 protein coding gene Chr3:150013822-150276840 (+)
FVB/NJ MGP_FVBNJ_G0027777
 protein coding gene Chr3:147388460-147647480 (+)
LP/J MGP_LPJ_G0027921
 protein coding gene Chr3:157954172-158230881 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027810
 protein coding gene Chr3:176085671-176368457 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028467
 protein coding gene Chr3:154581104-154851438 (+)
PWK/PhJ MGP_PWKPhJ_G0026871
 protein coding gene Chr3:149910889-150175848 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026699
 protein coding gene Chr3:152732382-153002859 (+)
WSB/EiJ MGP_WSBEiJ_G0027228
 protein coding gene Chr3:155574403-155845259 (+)



Homology
more
  • Human Ortholog
    PIGK, phosphatidylinositol glycan anchor biosynthesis class K
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIGK, phosphatidylinositol glycan anchor biosynthesis class K
  • Synonyms
    GPI8, NEDHCAS
  • Links
    NCBI Gene ID: 10026
    neXtProt AC: NX_Q92643
    UniProt: Q92643

  • Chr Location
    1p31.1; chr1:77088989-77219430 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for two human disease associated mutations is embryonic lethal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    101
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 329777 NCBI Gene Model | MGI Sequence Detail 128988 C57BL/6J ±  kb
transcript NM_178016 RefSeq | MGI Sequence Detail 4885 ZRU/MplStud  
polypeptide Q9CXY9 UniProt | EBI | MGI Sequence Detail 395 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 103
    cDNA 103

    Microarray probesets 6
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory