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Sorcs3 Gene Detail
Summary
  • Symbol
    Sorcs3
  • Name
    sortilin-related VPS10 domain containing receptor 3
  • Synonyms
    6330404A12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913923
    NCBI Gene: 66673
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:48194464-48793944 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 41.32 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    17367 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913923
 protein coding gene Chr19:48194464-48793944 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025238
 protein coding gene Chr19:48097992-48735046 (+)
A/J MGP_AJ_G0025214
 protein coding gene Chr19:45676169-46280063 (+)
AKR/J MGP_AKRJ_G0025183
 protein coding gene Chr19:47157026-47768257 (+)
BALB/cJ MGP_BALBcJ_G0025209
 protein coding gene Chr19:45726357-46331629 (+)
C3H/HeJ MGP_C3HHeJ_G0024969
 protein coding gene Chr19:47326250-47949120 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025652
 protein coding gene Chr19:49219092-49874159 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023065
 protein coding gene Chr19:44867032-45460215 (+)
CAST/EiJ MGP_CASTEiJ_G0024434
 protein coding gene Chr19:47160652-47831830 (+)
CBA/J MGP_CBAJ_G0024949
 protein coding gene Chr19:51700404-52390698 (+)
DBA/2J MGP_DBA2J_G0025081
 protein coding gene Chr19:45489554-46105578 (+)
FVB/NJ MGP_FVBNJ_G0025042
 protein coding gene Chr19:45258798-45857739 (+)
LP/J MGP_LPJ_G0025167
 protein coding gene Chr19:47978286-48605770 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025073
 protein coding gene Chr19:50916605-51565979 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025710
 protein coding gene Chr19:47281791-47905008 (+)
PWK/PhJ MGP_PWKPhJ_G0024183
 protein coding gene Chr19:45451913-46087881 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023986
 protein coding gene Chr19:45940986-46580791 (+)
WSB/EiJ MGP_WSBEiJ_G0024504
 protein coding gene Chr19:47430555-48056881 (+)



Homology
more
  • Human Ortholog
    SORCS3, sortilin related VPS10 domain containing receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SORCS3, sortilin related VPS10 domain containing receptor 3
  • Synonyms
    SORCS
  • Links
    NCBI Gene ID: 22986
    neXtProt AC: NX_Q9UPU3
    UniProt: Q9UPU3

  • Chr Location
    10q25.1; chr10:104641290-105265242 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit absent NMDA and glutamate receptor-dependent long term depression, impaired spatial learning and memory and impaired fear memory.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    922
  • Tissues
    105
  • cDNA Data
    12
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 66673 NCBI Gene Model | MGI Sequence Detail 599481 C57BL/6J ±  kb
transcript NM_025696 RefSeq | MGI Sequence Detail 5634 C57BL/6  
polypeptide Q8VI51 UniProt | EBI | MGI Sequence Detail 1219 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 12

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147683
References
more
  • Summaries
    All 28
    Developmental Gene Expression 4
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:286533 Tenney AP, et al., Etv1 Controls the Establishment of Non-overlapping Motor Innervation of Neighboring Facial Muscles during Development. Cell Rep. 2019 Oct 8;29(2):437-452.e4
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory