Lrrk2 MGI Mouse Gene Detail - MGI:1913975 - leucine-rich repeat kinase 2

Symbol

Lrrk2
Name

leucine-rich repeat kinase 2
Synonyms

4921513O20Rik, 9330188B09Rik, cI-46, D630001M17Rik, LOC381026

Feature Type

protein coding gene
IDs

MGI:1913975
NCBI Gene: 66725
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr15:91557378-91700323 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 46.07 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

5009 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913975	protein coding gene	Chr15:91556994-91700327 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022249	protein coding gene	Chr15:92994217-93150786 (+)
A/J	MGP_AJ_G0022208	protein coding gene	Chr15:89396485-89549433 (+)
AKR/J	MGP_AKRJ_G0022183	protein coding gene	Chr15:92046349-92200589 (+)
BALB/cJ	MGP_BALBcJ_G0022214	protein coding gene	Chr15:89525719-89670200 (+)
C3H/HeJ	MGP_C3HHeJ_G0021984	protein coding gene	Chr15:92059750-92214568 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022659	protein coding gene	Chr15:96390668-96547033 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020185	protein coding gene	Chr15:85529382-85670621 (+)
CAST/EiJ	MGP_CASTEiJ_G0021506	protein coding gene	Chr15:92888108-93034012 (+)
CBA/J	MGP_CBAJ_G0021951	protein coding gene	Chr15:99622645-99794961 (+)
DBA/2J	MGP_DBA2J_G0022078	protein coding gene	Chr15:88835507-88985313 (+)
FVB/NJ	MGP_FVBNJ_G0022057	protein coding gene	Chr15:87880227-88027271 (+)
LP/J	MGP_LPJ_G0022149	protein coding gene	Chr15:93127343-93281936 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022077	protein coding gene	Chr15:103996867-104164435 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022674	protein coding gene	Chr15:92160768-92316152 (+)
PWK/PhJ	MGP_PWKPhJ_G0021247	protein coding gene	Chr15:88901569-89048487 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0021081	protein coding gene	Chr15:91897639-92045056 (+)
WSB/EiJ	MGP_WSBEiJ_G0021555	protein coding gene	Chr15:92616351-92769151 (+)

Human Ortholog

LRRK2, leucine rich repeat kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LRRK2, leucine rich repeat kinase 2
Synonyms

AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Links

HGNC:18618

NCBI Gene ID: 120892

neXtProt AC: NX_Q5S007

UniProt: Q5S007
Chr Location

12q12

MGI Vertebrate Homology

Lrrk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LRRK2
Gene Tree

Lrrk2

Diseases

1 with Lrrk2 mouse models; 5 with human LRRK2 associations

Human Disease

Mouse Models

Parkinson's disease 8

IDs

View 1 model

IDs

IDs

IDs

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

71 phenotypes from 20 alleles in 15 genetic backgrounds
7 phenotypes from multigenic genotypes
169 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

41
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

2
Targeted

30
Transgenic

2
Genomic Mutations

4 involving Lrrk2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

159 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy.

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All GO Annotations

312
GO References

39

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1224
Tissues

250
cDNA Data

29
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lrrk2

ZFIN lrrk2

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All Sequences

51
RefSeq

7
UniProt

3
CCDS

CCDS37180.1

Ensembl

ENSMUSG00000036273 (Evidence)
NCBI Gene

66725

			Length	Strain/Species	Flank
genomic	ENSMUSG00000036273	Ensembl Gene Model \| MGI Sequence Detail	142946	C57BL/6J	± kb
transcript	ENSMUST00000060642	Ensembl \| MGI Sequence Detail	8275	Not Applicable
polypeptide	ENSMUSP00000052584	Ensembl \| MGI Sequence Detail	2527	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003033 leucine-rich repeat serine/threonine-protein kinase 2

(term hierarchy)
EC

2.7.11.1, 3.6.5.-
InterPro Domains

IPR036770 Ankyrin repeat-containing domain superfamily

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR032171 C-terminal of Roc (COR) domain

IPR001611 Leucine-rich repeat

IPR032675 Leucine-rich repeat domain superfamily

IPR003591 Leucine-rich repeat, typical subtype

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR020859 Roc domain

IPR008271 Serine/threonine-protein kinase, active site

IPR051420 Ser/Thr Protein Kinases with Diverse Regulatory Roles

IPR005225 Small GTP-binding protein domain

IPR053215 TKL Ser/Thr protein kinase

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 43

cDNA 30

Primer pair 13

Microarray probesets 4

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MGI:1930800, MGI:2442391, MGI:2685773

Summaries

All 279

Developmental Gene Expression 6

Diseases 2

Gene Ontology 39

Phenotypes 169
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:354845 Heaton GR, et al., Targeting Specific Kinase Substrates Rescues Increased Colitis Severity Induced by the Crohn's Disease-Linked LRRK2-N2081D Variant. bioRxiv. 2024 Sep 5;

TSS for Lrrk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132716	Chr15:91556435-91556453 (+)	-934 bp
Tssr132717	Chr15:91557253-91557262 (+)	-120 bp
Tssr132718	Chr15:91557263-91557279 (+)	-107 bp
Tssr132719	Chr15:91557285-91557308 (+)	-81 bp
Tssr132720	Chr15:91557333-91557344 (+)	-39 bp
Tssr132721	Chr15:91557388-91557471 (+)	52 bp
Tssr132722	Chr15:91557484-91557496 (+)	112 bp
Tssr4696	Chr15:91557541-91557550 (+)	168 bp
Tssr132723	Chr15:91557575-91557586 (+)	203 bp
Tssr132724	Chr15:91557696-91557710 (+)	325 bp
Tssr132725	Chr15:91561219-91561223 (+)	3,843 bp
Tssr132726	Chr15:91590796-91590808 (+)	33,424 bp
Tssr132727	Chr15:91590921-91590924 (+)	33,545 bp
Tssr132728	Chr15:91655572-91655577 (+)	98,197 bp
Tssr132729	Chr15:91656477-91656486 (+)	99,104 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24