About   Help   FAQ
Rnf220 Gene Detail
Summary
  • Symbol
    Rnf220
  • Name
    ring finger protein 220
  • Synonyms
    4931406I20Rik, 5730503K05Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1913993
    NCBI Gene: 66743
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:117128660-117354249 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 53.44 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5399 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1913993
 protein coding gene Chr4:117128660-117354249 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028650
 protein coding gene Chr4:118244836-118486500 (-)
A/J MGP_AJ_G0028611
 protein coding gene Chr4:113676832-113917689 (-)
AKR/J MGP_AKRJ_G0028561
 protein coding gene Chr4:116166617-116414326 (-)
BALB/cJ MGP_BALBcJ_G0028632
 protein coding gene Chr4:114308908-114541852 (-)
C3H/HeJ MGP_C3HHeJ_G0028346
 protein coding gene Chr4:117757701-117995028 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029073
 protein coding gene Chr4:122814309-123049986 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026357
 protein coding gene Chr4:107719649-107945999 (-)
CAST/EiJ MGP_CASTEiJ_G0027780
 protein coding gene Chr4:114957213-115198865 (-)
CBA/J MGP_CBAJ_G0028313
 protein coding gene Chr4:126166749-126417478 (-)
DBA/2J MGP_DBA2J_G0028461
 protein coding gene Chr4:114311105-114539509 (-)
FVB/NJ MGP_FVBNJ_G0028429
 protein coding gene Chr4:112818801-113050396 (-)
LP/J MGP_LPJ_G0028563
 protein coding gene Chr4:118420644-118659672 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028456
 protein coding gene Chr4:131110925-131346895 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029110
 protein coding gene Chr4:117317655-117548987 (-)
PWK/PhJ MGP_PWKPhJ_G0027506
 protein coding gene Chr4:111118943-111352274 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027329
 protein coding gene Chr4:113636461-113870446 (-)
WSB/EiJ MGP_WSBEiJ_G0027859
 protein coding gene Chr4:117199075-117450880 (-)



Homology
more
  • Human Ortholog
    RNF220, ring finger protein 220
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RNF220, ring finger protein 220
  • Synonyms
    C1orf164, HLD23
  • Links
    NCBI Gene ID: 55182
    neXtProt AC: NX_Q5VTB9
    UniProt: Q5VTB9

  • Chr Location
    1p34.1; chr1:44404783-44651724 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RNF220 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout results in the reduction of the number of motor neurons and some types of spinal interneurons and the increase of other types of spinal interneurons in embryos.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    809
  • Tissues
    68
  • cDNA Data
    15
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 66743 NCBI Gene Model | MGI Sequence Detail 225590 C57BL/6J ±  kb
    transcript NM_025739 RefSeq | MGI Sequence Detail 3043 C57BL/6  
    polypeptide Q6PDX6 UniProt | EBI | MGI Sequence Detail 566 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 15
      Primer pair 1
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1917863, MGI:2140538
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 11
      Gene Ontology 9
      Phenotypes 26
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory