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Tmtc2 Gene Detail
Summary
  • Symbol
    Tmtc2
  • Name
    transmembrane and tetratricopeptide repeat containing 2
  • Synonyms
    8430438D04Rik, D330034A10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914057
    NCBI Gene: 278279
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:105023524-105410312 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 54.72 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12872 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914057
 protein coding gene Chr10:105023524-105410340 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017702
 protein coding gene Chr10:107268818-107676834 (-)
A/J MGP_AJ_G0017679
 protein coding gene Chr10:103287756-103678680 (-)
AKR/J MGP_AKRJ_G0017641
 protein coding gene Chr10:106292681-106707172 (-)
BALB/cJ MGP_BALBcJ_G0017643
 protein coding gene Chr10:103668794-104071792 (-)
C3H/HeJ MGP_C3HHeJ_G0017468
 protein coding gene Chr10:106327637-106741118 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018100
 protein coding gene Chr10:111012544-111430173 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015779
 protein coding gene Chr10:98336115-98717959 (-)
CAST/EiJ MGP_CASTEiJ_G0017029
 protein coding gene Chr10:106428305-106862624 (-)
CBA/J MGP_CBAJ_G0017437
 protein coding gene Chr10:115295523-115730580 (-)
DBA/2J MGP_DBA2J_G0017542
 protein coding gene Chr10:102392394-102786145 (-)
FVB/NJ MGP_FVBNJ_G0017536
 protein coding gene Chr10:101473395-101867522 (-)
LP/J MGP_LPJ_G0017616
 protein coding gene Chr10:107889424-108305475 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017566
 protein coding gene Chr10:117586784-118025342 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018138
 protein coding gene Chr10:106252848-106668851 (-)
PWK/PhJ MGP_PWKPhJ_G0016811
 protein coding gene Chr10:102466775-102862799 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016601
 protein coding gene Chr10:104988105-105422572 (-)
WSB/EiJ MGP_WSBEiJ_G0017089
 protein coding gene Chr10:106363466-106780330 (-)



Homology
more
  • Human Ortholog
    TMTC2, transmembrane O-mannosyltransferase targeting cadherins 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMTC2, transmembrane O-mannosyltransferase targeting cadherins 2
  • Synonyms
    IBDBP1
  • Links
    NCBI Gene ID: 160335
    neXtProt AC: NX_Q8N394
    UniProt: Q8N394

  • Chr Location
    12q21.31; chr12:82686880-83134870 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1054
  • Tissues
    40
  • cDNA Data
    32
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000036019 Ensembl Gene Model | MGI Sequence Detail 386789 C57BL/6J ±  kb
    transcript ENSMUST00000061506 Ensembl | MGI Sequence Detail 5629 Not Applicable  
    polypeptide ENSMUSP00000061919 Ensembl | MGI Sequence Detail 836 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 32

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2444719
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory