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Cab39l Gene Detail
Summary
  • Symbol
    Cab39l
  • Name
    calcium binding protein 39-like
  • Synonyms
    1500031K13Rik, 2810425O13Rik, 4930520C08Rik, MO2L
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914081
    NCBI Gene: 69008
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:59678400-59786353 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 31.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2050 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914081
 protein coding gene Chr14:59678400-59823213 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021425
 protein coding gene Chr14:53742057-53864503 (+)
A/J MGP_AJ_G0021384
 protein coding gene Chr14:52614933-52724827 (+)
AKR/J MGP_AKRJ_G0021359
 protein coding gene Chr14:54474929-54598357 (+)
BALB/cJ MGP_BALBcJ_G0021389
 protein coding gene Chr14:52576391-52686733 (+)
C3H/HeJ MGP_C3HHeJ_G0021167
 protein coding gene Chr14:54133478-54255524 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021828
 protein coding gene Chr14:56413408-56543067 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019368
 protein coding gene Chr14:50672456-50762563 (+)
CAST/EiJ MGP_CASTEiJ_G0020683
 protein coding gene Chr14:50545754-50664663 (+)
CBA/J MGP_CBAJ_G0021134
 protein coding gene Chr14:58006245-58136706 (+)
DBA/2J MGP_DBA2J_G0021257
 protein coding gene Chr14:52285069-52396840 (+)
FVB/NJ MGP_FVBNJ_G0021235
 protein coding gene Chr14:51699813-51807697 (+)
LP/J MGP_LPJ_G0021331
 protein coding gene Chr14:54771564-54891118 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021264
 protein coding gene Chr14:57420726-57543734 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021851
 protein coding gene Chr14:53622618-53736158 (+)
PWK/PhJ MGP_PWKPhJ_G0020427
 protein coding gene Chr14:48924055-49037418 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020260
 protein coding gene Chr14:49630859-49740933 (+)
WSB/EiJ MGP_WSBEiJ_G0020736
 protein coding gene Chr14:53938833-54056558 (+)



Homology
more
  • Human Ortholog
    CAB39L, calcium binding protein 39 like
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CAB39L, calcium binding protein 39 like
  • Synonyms
    bA103J18.3, MLAA-34, MO25-BETA, MO2L
  • Links
    NCBI Gene ID: 81617
    neXtProt AC: NX_Q9H9S4
    UniProt: Q9H9S4

  • Chr Location
    13q14.2; chr13:49308650-49444064 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show dysregulated basal-to-luminal urothelial differentiation, with expansion of the basal undifferentiated layer of the bladder urothelium, and show increased susceptibility to tobacco-related carcinogen BBN-induced basal bladder cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    797
  • Tissues
    60
  • cDNA Data
    99
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 69008 NCBI Gene Model | MGI Sequence Detail 107954 C57BL/6J ±  kb
    transcript NM_001360591 RefSeq | MGI Sequence Detail 3113 C57BL/6  
    polypeptide Q9DB16 UniProt | EBI | MGI Sequence Detail 337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 99

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916258, MGI:1922871, MGI:2145574
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 3
      Gene Ontology 1
      Phenotypes 20
    • Earliest
      J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
    • Latest
      J:358384 Ferdaus MZ, et al., Kinase Scaffold Cab39 Is Necessary for Phospho-Activation of the Thiazide-Sensitive NCC. Hypertension. 2024 Apr;81(4):801-810
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory