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Sdhd Gene Detail
Summary
  • Symbol
    Sdhd
  • Name
    succinate dehydrogenase complex, subunit D, integral membrane protein
  • Synonyms
    3110001M13Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914175
    NCBI Gene: 66925
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:50507657-50515112 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 27.75 cM, cytoband B
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    222 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914175
 protein coding gene Chr9:50507640-50515149 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034781
 protein coding gene Chr9:49495620-49503145 (-)
A/J MGP_AJ_G0034762
 protein coding gene Chr9:47979984-47987495 (-)
AKR/J MGP_AKRJ_G0034690
 protein coding gene Chr9:48991647-48999157 (-)
BALB/cJ MGP_BALBcJ_G0034754
 protein coding gene Chr9:47707655-47715166 (-)
C3H/HeJ MGP_C3HHeJ_G0034464
 protein coding gene Chr9:49479089-49486600 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035274
 protein coding gene Chr9:50872290-50879801 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032187
 protein coding gene Chr9:47447860-47455826 (-)
CAST/EiJ MGP_CASTEiJ_G0033786
 protein coding gene Chr9:49427694-49435206 (-)
CBA/J MGP_CBAJ_G0034436
 protein coding gene Chr9:52685534-52693045 (-)
DBA/2J MGP_DBA2J_G0034595
 protein coding gene Chr9:47844282-47851765 (-)
FVB/NJ MGP_FVBNJ_G0034536
 protein coding gene Chr9:47061180-47068730 (-)
LP/J MGP_LPJ_G0034676
 protein coding gene Chr9:49855815-49863340 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034579
 protein coding gene Chr9:54281836-54289346 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035295
 protein coding gene Chr9:48969672-48977183 (-)
PWK/PhJ MGP_PWKPhJ_G0033491
 protein coding gene Chr9:47821000-47828596 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033326
 protein coding gene Chr9:49280902-49288401 (-)
WSB/EiJ MGP_WSBEiJ_G0033899
 protein coding gene Chr9:48975048-48983815 (-)



Homology
more
  • Human Ortholog
    SDHD, succinate dehydrogenase complex subunit D
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SDHD, succinate dehydrogenase complex subunit D
  • Synonyms
    CBT1, CII-4, CWS3, cybS, MC2DN3, PGL, PGL1, PPGL1, QPs3, SDH4
  • Links
    NCBI Gene ID: 6392
    neXtProt AC: NX_O14521
    UniProt: O14521

  • Chr Location
    11q23.1; chr11:112086824-112120016 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human SDHD associations

Human Disease Mouse Models
      
IDs
IDs
IDs
 View 3 "NOT" models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 3 alleles in 5 genetic backgrounds
    4 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die before E7.5. Heterozygotes show a deficiency in succinate dehydrogenase activity and an abnormal enhancement of resting carotid body activity due to a decrease of potassium conductance and persistent calcium influx into glomus cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    138
  • cDNA Data
    13
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000171 Ensembl Gene Model | MGI Sequence Detail 7456 C57BL/6J ±  kb
    transcript ENSMUST00000000175 Ensembl | MGI Sequence Detail 1231 Not Applicable  
    polypeptide ENSMUSP00000000175 Ensembl | MGI Sequence Detail 159 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR034804 Fumarate reductase/succinate dehydrogenase, transmembrane subunit
      IPR007992 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, CybS
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 13
      Primer pair 4
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143396
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 12
      Phenotypes 17
    • Earliest
      J:320283 Corbin JD, et al., Studies of cGMP analog specificity and function of the two intrasubunit binding sites of cGMP-dependent protein kinase. J Biol Chem. 1986 Jan 25;261(3):1208-14
    • Latest
      J:346910 Ayyangar U, et al., Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory