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Thap4 Gene Detail
Summary
  • Symbol
    Thap4
  • Name
    THAP domain containing 4
  • Synonyms
    2010320B01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914276
    NCBI Gene: 67026
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:93633113-93682560 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 47.29 cM, cytoband D
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1299 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914276
 protein coding gene Chr1:93629657-93682586 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016347
 protein coding gene Chr1:95342183-95398270 (-)
A/J MGP_AJ_G0016328
 protein coding gene Chr1:91928380-91982029 (-)
AKR/J MGP_AKRJ_G0016289
 protein coding gene Chr1:94637184-94692400 (-)
BALB/cJ MGP_BALBcJ_G0016284
 protein coding gene Chr1:92106068-92159246 (-)
C3H/HeJ MGP_C3HHeJ_G0016113
 protein coding gene Chr1:94896456-94952789 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016743
 protein coding gene Chr1:98962569-99020884 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014461
 protein coding gene Chr1:86170486-86223203 (-)
CAST/EiJ MGP_CASTEiJ_G0015696
 protein coding gene Chr1:94231055-94286618 (-)
CBA/J MGP_CBAJ_G0016087
 protein coding gene Chr1:102175104-102232804 (-)
DBA/2J MGP_DBA2J_G0016192
 protein coding gene Chr1:91134197-91186184 (-)
FVB/NJ MGP_FVBNJ_G0016191
 protein coding gene Chr1:90194267-90247614 (-)
LP/J MGP_LPJ_G0016263
 protein coding gene Chr1:96519466-96579486 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016216
 protein coding gene Chr1:105262863-105315864 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016782
 protein coding gene Chr1:94662346-94729816 (-)
PWK/PhJ MGP_PWKPhJ_G0015481
 protein coding gene Chr1:90560200-90614627 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015265
 protein coding gene Chr1:93605118-93662074 (-)
WSB/EiJ MGP_WSBEiJ_G0015756
 protein coding gene Chr1:94480747-94543259 (-)



Homology
more
  • Human Ortholog
    THAP4, THAP domain containing 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THAP4, THAP domain containing 4
  • Synonyms
    CGI-36, Nb(III), PP238
  • Links
    NCBI Gene ID: 51078
    neXtProt AC: NX_Q8WY91
    UniProt: Q8WY91

  • Chr Location
    2q37.3; chr2:241584405-241637576 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit dwarfism. Males have increased thymus weight, small testes, and degeneration of seminiferous tubules but are fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    30
  • cDNA Data
    72
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67026 NCBI Gene Model | MGI Sequence Detail 49448 C57BL/6J ±  kb
    transcript NM_025920 RefSeq | MGI Sequence Detail 2160 C57BL/6  
    polypeptide Q6P3Z3 UniProt | EBI | MGI Sequence Detail 569 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      cDNA 73
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 6
      Gene Ontology 4
      Phenotypes 7
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:350810 Katayama K, et al., Mutation of the Thap4 gene causes dwarfism and testicular anomalies in rats and mice. Mamm Genome. 2024 Jun;35(2):149-159
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory