About   Help   FAQ
Oxct1 Gene Detail
Summary
  • Symbol
    Oxct1
  • Name
    3-oxoacid CoA transferase 1
  • Synonyms
    2610008O03Rik, Scot-s
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914291
    NCBI Gene: 67041
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:4055910-4184826 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 1.86 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3643 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914291
 protein coding gene Chr15:4055865-4184826 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021685
 protein coding gene Chr15:893831-1034490 (+)
A/J MGP_AJ_G0021645
 protein coding gene Chr15:921084-1055168 (+)
AKR/J MGP_AKRJ_G0021623
 protein coding gene Chr15:905967-1036980 (+)
BALB/cJ MGP_BALBcJ_G0021652
 protein coding gene Chr15:881032-1015855 (+)
C3H/HeJ MGP_C3HHeJ_G0021428
 protein coding gene Chr15:916817-1053682 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022091
 protein coding gene Chr15:980027-1126062 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019629
 protein coding gene Chr15:770148-894643 (+)
CAST/EiJ MGP_CASTEiJ_G0020944
 protein coding gene Chr15:913218-1056629 (+)
CBA/J MGP_CBAJ_G0021397
 protein coding gene Chr15:961771-1118401 (+)
DBA/2J MGP_DBA2J_G0021521
 protein coding gene Chr15:894697-1025025 (+)
FVB/NJ MGP_FVBNJ_G0021499
 protein coding gene Chr15:844117-974373 (+)
LP/J MGP_LPJ_G0021588
 protein coding gene Chr15:875123-1007980 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021525
 protein coding gene Chr15:1016319-1163759 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022114
 protein coding gene Chr15:886977-1027370 (+)
PWK/PhJ MGP_PWKPhJ_G0020688
 protein coding gene Chr15:902569-1046271 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020526
 protein coding gene Chr15:959466-1147149 (+)
WSB/EiJ MGP_WSBEiJ_G0021000
 protein coding gene Chr15:874621-1014440 (+)



Homology
more
  • Human Ortholog
    OXCT1, 3-oxoacid CoA-transferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    OXCT1, 3-oxoacid CoA-transferase 1
  • Synonyms
    OXCT, SCOT
  • Links
    NCBI Gene ID: 5019
    neXtProt AC: NX_P55809
    UniProt: P55809

  • Chr Location
    5p13.1; chr5:41730065-41870425 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit hyperketonemia, ketoacidosis, increased glucose oxidation in the brain, increased autophagy in the brain, and neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    3
  • cDNA Data
    379
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67041 NCBI Gene Model | MGI Sequence Detail 128917 C57BL/6J ±  kb
    transcript NM_024188 RefSeq | MGI Sequence Detail 3496 C57BL/6  
    polypeptide Q9D0K2 UniProt | EBI | MGI Sequence Detail 520 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 381
      cDNA 379
      Primer pair 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:346093 Ma W, et al., OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB. Mol Cell. 2024 Feb 1;84(3):538-551.e7
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory