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Tbc1d7 Gene Detail
Summary
  • Symbol
    Tbc1d7
  • Name
    TBC1 domain family, member 7
  • Synonyms
    2610009C09Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914296
    NCBI Gene: 67046
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:43305216-43324977 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 21.31 cM, cytoband A5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    756 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914296
 protein coding gene Chr13:43305214-43324977 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020496
 protein coding gene Chr13:41733840-41754318 (-)
A/J MGP_AJ_G0020450
 protein coding gene Chr13:40327826-40347519 (-)
AKR/J MGP_AKRJ_G0020428
 protein coding gene Chr13:41439820-41459577 (-)
BALB/cJ MGP_BALBcJ_G0020446
 protein coding gene Chr13:40535558-40558391 (-)
C3H/HeJ MGP_C3HHeJ_G0020245
 protein coding gene Chr13:41300024-41327925 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020879
 protein coding gene Chr13:43031686-43053614 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018466
 protein coding gene Chr13:38425121-38444916 (-)
CAST/EiJ MGP_CASTEiJ_G0019760
 protein coding gene Chr13:41136554-41158206 (-)
CBA/J MGP_CBAJ_G0020206
 protein coding gene Chr13:44863073-44884016 (-)
DBA/2J MGP_DBA2J_G0020328
 protein coding gene Chr13:39890639-39910185 (-)
FVB/NJ MGP_FVBNJ_G0020307
 protein coding gene Chr13:39398933-39426808 (-)
LP/J MGP_LPJ_G0020403
 protein coding gene Chr13:41980993-42001713 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020336
 protein coding gene Chr13:44768560-44788872 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020922
 protein coding gene Chr13:41100098-41120371 (-)
PWK/PhJ MGP_PWKPhJ_G0019515
 protein coding gene Chr13:40001559-40021792 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019345
 protein coding gene Chr13:39733713-39753222 (-)
WSB/EiJ MGP_WSBEiJ_G0019822
 protein coding gene Chr13:41409788-41437084 (-)



Homology
more
  • Human Ortholog
    TBC1D7, TBC1 domain family member 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBC1D7, TBC1 domain family member 7
  • Synonyms
    MGCPH, PIG51, TBC7
  • Links
    NCBI Gene ID: 51256
    neXtProt AC: NX_Q9P0N9
    UniProt: Q9P0N9

  • Chr Location
    6p24.1; chr6:13266542-13328583 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced neuron specification, increased brain weight, reduced gripe strength, hypoactivity, abnormal gait, and increased lean body mass.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    6
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021368 Ensembl Gene Model | MGI Sequence Detail 19762 C57BL/6J ±  kb
    transcript ENSMUST00000021797 Ensembl | MGI Sequence Detail 1239 Not Applicable  
    polypeptide ENSMUSP00000021797 Ensembl | MGI Sequence Detail 293 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 3
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:325096 Schrotter S, et al., The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth. Cell Rep. 2022 May 17;39(7):110824
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory