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Nkap Gene Detail
Summary
  • Symbol
    Nkap
  • Name
    NFKB activating protein
  • Synonyms
    2610020O08Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914300
    NCBI Gene: 67050
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:36390448-36414399 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 21.54 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    492 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914300
 protein coding gene ChrX:36390416-36414399 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035632
 protein coding gene ChrX:32076673-32100500 (+)
A/J MGP_AJ_G0035609
 protein coding gene ChrX:32138263-32163480 (+)
AKR/J MGP_AKRJ_G0035542
 protein coding gene ChrX:32870094-32893891 (+)
BALB/cJ MGP_BALBcJ_G0035602
 protein coding gene ChrX:31861599-31885558 (+)
C3H/HeJ MGP_C3HHeJ_G0035320
 protein coding gene ChrX:32386927-32411614 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036138
 protein coding gene ChrX:32709613-32735936 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033000
 protein coding gene ChrX:30350322-30373477 (+)
CAST/EiJ MGP_CASTEiJ_G0034610
 protein coding gene ChrX:20544982-20570117 (+)
CBA/J MGP_CBAJ_G0035289
 protein coding gene ChrX:33574735-33605584 (+)
DBA/2J MGP_DBA2J_G0035440
 protein coding gene ChrX:31953597-31978315 (+)
FVB/NJ MGP_FVBNJ_G0035387
 protein coding gene ChrX:31719532-31745524 (+)
LP/J MGP_LPJ_G0035522
 protein coding gene ChrX:32461473-32487024 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035431
 protein coding gene ChrX:34016370-34040393 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036145
 protein coding gene ChrX:32042975-32066607 (+)
PWK/PhJ MGP_PWKPhJ_G0034312
 protein coding gene ChrX:19996163-20019622 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034153
 protein coding gene ChrX:21025632-21049788 (+)
WSB/EiJ MGP_WSBEiJ_G0034746
 protein coding gene ChrX:31836705-31862572 (+)



Homology
more
  • Human Ortholog
    NKAP, NFKB activating protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKAP, NFKB activating protein
  • Synonyms
    MRXSHD
  • Links
    NCBI Gene ID: 79576
    neXtProt AC: NX_Q8N5F7
    UniProt: Q8N5F7

  • Chr Location
    Xq24; chrX:119920672-119943751 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NKAP associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in T cells exhibit impaired T cell differentiation at the DN3 stage with increased DN3 T cells and decreased total thymocytes, single positive T cells, and double positive T cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016409 Ensembl Gene Model | MGI Sequence Detail 23952 C57BL/6J ±  kb
    transcript ENSMUST00000016553 Ensembl | MGI Sequence Detail 4230 Not Applicable  
    polypeptide ENSMUSP00000016553 Ensembl | MGI Sequence Detail 415 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2147837, MGI:2147924, MGI:2147948
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:293523 Dash B, et al., The Interaction between NKAP and HDAC3 Is Critical for T Cell Maturation. Immunohorizons. 2019 Aug 6;3(8):352-367
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory