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Noa1 Gene Detail
Summary
  • Symbol
    Noa1
  • Name
    nitric oxide associated 1
  • Synonyms
    2610024G14Rik, mAtNOS1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914306
    NCBI Gene: 56412
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:77442029-77457931 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 41.64 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    596 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914306
 protein coding gene Chr5:77442016-77458276 (-)
129S1/SvImJ MGP_129S1SvImJ_G0029657
 protein coding gene Chr5:77564137-77582993 (-)
A/J MGP_AJ_G0029625
 protein coding gene Chr5:74565859-74581513 (-)
AKR/J MGP_AKRJ_G0029573
 protein coding gene Chr5:77018465-77038322 (-)
BALB/cJ MGP_BALBcJ_G0029634
 protein coding gene Chr5:75304786-75322420 (-)
C3H/HeJ MGP_C3HHeJ_G0029357
 protein coding gene Chr5:77376143-77394041 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030088
 protein coding gene Chr5:80643357-80658975 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027328
 protein coding gene Chr5:70300621-70316008 (-)
CAST/EiJ MGP_CASTEiJ_G0028765
 protein coding gene Chr5:76601241-76617562 (-)
CBA/J MGP_CBAJ_G0029326
 protein coding gene Chr5:83323161-83342687 (-)
DBA/2J MGP_DBA2J_G0029471
 protein coding gene Chr5:74623336-74640514 (-)
FVB/NJ MGP_FVBNJ_G0029432
 protein coding gene Chr5:73834117-73850632 (-)
LP/J MGP_LPJ_G0029558
 protein coding gene Chr5:77968787-77985835 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0029460
 protein coding gene Chr5:86412378-86437391 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030121
 protein coding gene Chr5:76563997-76583135 (-)
PWK/PhJ MGP_PWKPhJ_G0028488
 protein coding gene Chr5:73647816-73663417 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028323
 protein coding gene Chr5:75942592-75957608 (-)
WSB/EiJ MGP_WSBEiJ_G0028845
 protein coding gene Chr5:76889285-76905640 (-)



Homology
more
  • Human Ortholog
    NOA1, nitric oxide associated 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOA1, nitric oxide associated 1
  • Synonyms
    C4orf14, hAtNOS1, hNOA1, mAtNOS1, MTG3
  • Links
    NCBI Gene ID: 84273
    neXtProt AC: NX_Q8NC60
    UniProt: Q8NC60

  • Chr Location
    4q12; chr4:56963350-56977606 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality during organogenesis associated with developmental retardation, decreased cell proliferation and apoptosis, increased cell necrosis, and abnormal mitochondrial morphology and physiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    38
  • cDNA Data
    47
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000036285 Ensembl Gene Model | MGI Sequence Detail 15903 C57BL/6J ±  kb
transcript ENSMUST00000047860 Ensembl | MGI Sequence Detail 2288 Not Applicable  
polypeptide ENSMUSP00000045948 Ensembl | MGI Sequence Detail 693 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000032304 nitric oxide-associated protein 1
    (term hierarchy)
  • InterPro Domains
    IPR030378 Circularly permuted (CP)-type guanine nucleotide-binding (G) domain
    IPR006073 GTP binding domain
    IPR052807 Mitochondrial translation and respiration regulator
    IPR048422 NOA1/YqeH-like, C-terminal domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 49
    cDNA 47
    Other 2

    Microarray probesets 2
Other
Accession IDs
less
MGI:2141063
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:204094 Al-Furoukh N, et al., Binding to G-quadruplex RNA activates the mitochondrial GTPase NOA1. Biochim Biophys Acta. 2013 Dec;1833(12):2933-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory