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Pgap4 Gene Detail
Summary
  • Symbol
    Pgap4
  • Name
    post-GPI attachment to proteins GalNAc transferase 4
  • Synonyms
    2810432L12Rik, 9330170P15Rik, Tmem246
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914313
    NCBI Gene: 67063
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:49584506-49597876 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 26.63 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    448 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914313
 protein coding gene Chr4:49584506-49597876 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028285
 protein coding gene Chr4:48065272-48078486 (-)
A/J MGP_AJ_G0028245
 protein coding gene Chr4:46286422-46299795 (-)
AKR/J MGP_AKRJ_G0028194
 protein coding gene Chr4:47503167-47516534 (-)
BALB/cJ MGP_BALBcJ_G0028264
 protein coding gene Chr4:46398588-46411901 (-)
C3H/HeJ MGP_C3HHeJ_G0027985
 protein coding gene Chr4:48059747-48073085 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028705
 protein coding gene Chr4:49798322-49811696 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026014
 protein coding gene Chr4:43492328-43505965 (-)
CAST/EiJ MGP_CASTEiJ_G0027424
 protein coding gene Chr4:47628811-47642184 (-)
CBA/J MGP_CBAJ_G0027951
 protein coding gene Chr4:51495129-51508513 (-)
DBA/2J MGP_DBA2J_G0028101
 protein coding gene Chr4:46171712-46185046 (-)
FVB/NJ MGP_FVBNJ_G0028068
 protein coding gene Chr4:45436684-45450087 (-)
LP/J MGP_LPJ_G0028200
 protein coding gene Chr4:48143855-48157107 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028092
 protein coding gene Chr4:54412935-54428598 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028740
 protein coding gene Chr4:47706322-47719700 (-)
PWK/PhJ MGP_PWKPhJ_G0027149
 protein coding gene Chr4:46246740-46260193 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026977
 protein coding gene Chr4:47086877-47100492 (-)
WSB/EiJ MGP_WSBEiJ_G0027502
 protein coding gene Chr4:47606247-47621681 (-)



Homology
more
  • Human Ortholog
    PGAP4, post-GPI attachment to proteins GalNAc transferase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGAP4, post-GPI attachment to proteins GalNAc transferase 4
  • Synonyms
    C9orf125, TMEM246
  • Links
    NCBI Gene ID: 84302
    neXtProt AC: NX_Q9BRR3
    UniProt: Q9BRR3

  • Chr Location
    9q31.1; chr9:101473170-101533686 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show increased blood alkaline phosphatase level, impaired bone formation, reduced locomotor activity, impaired memory, and increased susceptibility to prion infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    787
  • Tissues
    11
  • cDNA Data
    38
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67063 NCBI Gene Model | MGI Sequence Detail 13371 C57BL/6J ±  kb
    transcript NM_001355503 RefSeq | MGI Sequence Detail 3008 C57BL/6  
    polypeptide Q91YV9 UniProt | EBI | MGI Sequence Detail 403 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 39

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1924513, MGI:2140362, MGI:6390557
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 3
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:333707 Hirata T, et al., Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathology. J Biol Chem. 2022 Feb 10;:101720
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory