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Abhd2 Gene Detail
Summary
  • Symbol
    Abhd2
  • Name
    abhydrolase domain containing 2
  • Synonyms
    2210009N18Rik, LABH2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914344
    NCBI Gene: 54608
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:78923002-79015257 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 44.96 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2027 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914344
 protein coding gene Chr7:78922947-79015257 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032386
 protein coding gene Chr7:81148966-81237882 (+)
A/J MGP_AJ_G0032365
 protein coding gene Chr7:79283062-79370507 (+)
AKR/J MGP_AKRJ_G0032301
 protein coding gene Chr7:80980208-81069118 (+)
BALB/cJ MGP_BALBcJ_G0032377
 protein coding gene Chr7:78980467-79069474 (+)
C3H/HeJ MGP_C3HHeJ_G0032090
 protein coding gene Chr7:81646003-81735253 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032869
 protein coding gene Chr7:84343934-84435247 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029877
 protein coding gene Chr7:81827944-81914497 (+)
CAST/EiJ MGP_CASTEiJ_G0031418
 protein coding gene Chr7:72510607-72600710 (+)
CBA/J MGP_CBAJ_G0032056
 protein coding gene Chr7:87177168-87266704 (+)
DBA/2J MGP_DBA2J_G0032211
 protein coding gene Chr7:77862012-77949452 (+)
FVB/NJ MGP_FVBNJ_G0032166
 protein coding gene Chr7:77771959-77859166 (+)
LP/J MGP_LPJ_G0032292
 protein coding gene Chr7:82400785-82497460 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032203
 protein coding gene Chr7:87369081-87459332 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032887
 protein coding gene Chr7:80436099-80523431 (+)
PWK/PhJ MGP_PWKPhJ_G0031138
 protein coding gene Chr7:71024877-71110046 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030979
 protein coding gene Chr7:67424266-67511945 (+)
WSB/EiJ MGP_WSBEiJ_G0031536
 protein coding gene Chr7:80752048-80843371 (+)



Homology
more
  • Human Ortholog
    ABHD2, abhydrolase domain containing 2, acylglycerol lipase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABHD2, abhydrolase domain containing 2, acylglycerol lipase
  • Synonyms
    HS1-2, LABH2, PHPS1-2
  • Links
    NCBI Gene ID: 11057
    neXtProt AC: NX_P08910
    UniProt: P08910

  • Chr Location
    15q26.1; chr15:89040998-89202355 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit enhanced migratory ability of cultured smooth muscle cells and significant intimal hyperplasia after cuff placement. Homozygotes for a null allele show altered ovarian follicle maturation, an increased number of atretic antral follicles, and a dysregulated estrous cycle with a prolonged estrus.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    39
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    61
  • cDNA Data
    9
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54608 NCBI Gene Model | MGI Sequence Detail 92256 C57BL/6J ±  kb
    transcript NM_018811 RefSeq | MGI Sequence Detail 2903 C57BL/6  
    polypeptide Q9QXM0 UniProt | EBI | MGI Sequence Detail 425 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 1
      cDNA 11
      Primer pair 4

      Microarray probesets 3
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345432 Price TR, et al., Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin. PLoS Genet. 2023 Jul;19(7):e1010713
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory