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Lpar6 Gene Detail
Summary
  • Symbol
    Lpar6
  • Name
    lysophosphatidic acid receptor 6
  • Synonyms
    2610302I02Rik, P2ry5, P2y5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914418
    NCBI Gene: 67168
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:73475331-73477798 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 38.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914418
 protein coding gene Chr14:73475331-73480734 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021556
 protein coding gene Chr14:67975401-67980795 (+)
A/J MGP_AJ_G0021515
 protein coding gene Chr14:66489571-66494970 (+)
AKR/J MGP_AKRJ_G0021491
 protein coding gene Chr14:68441454-68446857 (+)
BALB/cJ MGP_BALBcJ_G0021521
 protein coding gene Chr14:66252971-66258370 (+)
C3H/HeJ MGP_C3HHeJ_G0021298
 protein coding gene Chr14:68167126-68172533 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021962
 protein coding gene Chr14:70968074-70973473 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019500
 protein coding gene Chr14:64210444-64215775 (+)
CAST/EiJ MGP_CASTEiJ_G0020816
 protein coding gene Chr14:64827212-64832573 (+)
CBA/J MGP_CBAJ_G0021266
 protein coding gene Chr14:73196707-73202098 (+)
DBA/2J MGP_DBA2J_G0021389
 protein coding gene Chr14:65873011-65878420 (+)
FVB/NJ MGP_FVBNJ_G0021367
 protein coding gene Chr14:65253343-65258665 (+)
LP/J MGP_LPJ_G0021459
 protein coding gene Chr14:69144120-69149465 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021396
 protein coding gene Chr14:72026750-72033136 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021984
 protein coding gene Chr14:67715683-67721082 (+)
PWK/PhJ MGP_PWKPhJ_G0020559
 protein coding gene Chr14:62642150-62647495 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020394
 protein coding gene Chr14:63683005-63688369 (+)
WSB/EiJ MGP_WSBEiJ_G0020869
 protein coding gene Chr14:68066268-68072800 (+)



Homology
more
  • Human Ortholog
    LPAR6, lysophosphatidic acid receptor 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LPAR6, lysophosphatidic acid receptor 6
  • Synonyms
    ARWH1, HYPT8, LAH3, LPA-6, P2RY5, P2Y5
  • Links
    NCBI Gene ID: 10161
    neXtProt AC: NX_P43657
    UniProt: P43657

  • Chr Location
    13q14.2; chr13:48389567-48444704 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human LPAR6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice show dysregulated basal-to-luminal urothelial differentiation, with hyperplasia of the luminal cells in the bladder urothelium, and show increased susceptibility to tobacco-related carcinogen BBN-induced luminal-type bladder cancer.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    842
  • Tissues
    74
  • cDNA Data
    56
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 67168 NCBI Gene Model | MGI Sequence Detail 2468 C57BL/6J ±  kb
    transcript NM_175116 RefSeq | MGI Sequence Detail 2468 C57BL/6  
    polypeptide Q8BMC0 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      cDNA 56
      Primer pair 7
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 24
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory