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Cdt1 Gene Detail
Summary
  • Symbol
    Cdt1
  • Name
    chromatin licensing and DNA replication factor 1
  • Synonyms
    2610318F11Rik, Ris2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914427
    NCBI Gene: 67177
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123294754-123299869 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 71.91 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    311 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914427
 protein coding gene Chr8:123294754-123300293 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034230
 protein coding gene Chr8:126119380-126124472 (+)
A/J MGP_AJ_G0034210
 protein coding gene Chr8:120895858-120901168 (+)
AKR/J MGP_AKRJ_G0034137
 protein coding gene Chr8:124418761-124423874 (+)
BALB/cJ MGP_BALBcJ_G0034204
 protein coding gene Chr8:121096697-121101810 (+)
C3H/HeJ MGP_C3HHeJ_G0033915
 protein coding gene Chr8:125119051-125124164 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034724
 protein coding gene Chr8:130332486-130338834 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031666
 protein coding gene Chr8:113730698-113735478 (+)
CAST/EiJ MGP_CASTEiJ_G0033242
 protein coding gene Chr8:125201874-125206947 (+)
CBA/J MGP_CBAJ_G0033888
 protein coding gene Chr8:135115412-135120525 (+)
DBA/2J MGP_DBA2J_G0034044
 protein coding gene Chr8:120085244-120090357 (+)
FVB/NJ MGP_FVBNJ_G0033987
 protein coding gene Chr8:119231479-119236592 (+)
LP/J MGP_LPJ_G0034133
 protein coding gene Chr8:126243163-126248255 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034034
 protein coding gene Chr8:137283785-137288898 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034742
 protein coding gene Chr8:124601020-124607493 (+)
PWK/PhJ MGP_PWKPhJ_G0032944
 protein coding gene Chr8:119908814-119914602 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032784
 protein coding gene Chr8:123329765-123334521 (+)
WSB/EiJ MGP_WSBEiJ_G0033358
 protein coding gene Chr8:125357159-125362269 (+)



Homology
more
  • Human Ortholog
    CDT1, chromatin licensing and DNA replication factor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDT1, chromatin licensing and DNA replication factor 1
  • Synonyms
    DUP, RIS2
  • Links
    NCBI Gene ID: 81620
    neXtProt AC: NX_Q9H211
    UniProt: Q9H211

  • Chr Location
    16q24.3; chr16:88803789-88809258 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CDT1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    2 phenotype references
Mice homozygous for a small in-frame deletion in exon 2 are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    765
  • Tissues
    10
  • cDNA Data
    113
  • Literature Summary
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 67177 NCBI Gene Model | MGI Sequence Detail 5116 C57BL/6J ±  kb
transcript NM_026014 RefSeq | MGI Sequence Detail 2245 Not Specified  
polypeptide Q8R4E9 UniProt | EBI | MGI Sequence Detail 557 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 116
    cDNA 113
    Primer pair 3

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142800, MGI:2142842
References
more
  • Summaries
    All 52
    Developmental Gene Expression 14
    Gene Ontology 10
    Phenotypes 2
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:336452 Petropoulos M, et al., Cdt1 overexpression drives colorectal carcinogenesis through origin overlicensing and DNA damage. J Pathol. 2023 Jan;259(1):10-20
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory