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Plxdc2 Gene Detail
Summary
  • Symbol
    Plxdc2
  • Name
    plexin domain containing 2
  • Synonyms
    1200007L24Rik, 5430431D22Rik, Tem7r
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914698
    NCBI Gene: 67448
  • Alliance
  • Transcription Start Sites
    51 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:16361115-16760650 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 11.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11499 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914698
protein coding gene Chr2:16360551-16765941 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025368
protein coding gene Chr2:13958526-14378997 (+)
A/J MGP_AJ_G0025346
protein coding gene Chr2:13421610-13817869 (+)
AKR/J MGP_AKRJ_G0025314
protein coding gene Chr2:13812134-14234303 (+)
BALB/cJ MGP_BALBcJ_G0025341
protein coding gene Chr2:13418799-13815721 (+)
C3H/HeJ MGP_C3HHeJ_G0025101
protein coding gene Chr2:13762732-14169824 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025783
protein coding gene Chr2:14290723-14707044 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023199
protein coding gene Chr2:12915940-13290930 (+)
CAST/EiJ MGP_CASTEiJ_G0024564
protein coding gene Chr2:13741632-14158599 (+)
CBA/J MGP_CBAJ_G0025080
protein coding gene Chr2:14945812-15388284 (+)
DBA/2J MGP_DBA2J_G0025212
protein coding gene Chr2:13329875-13728968 (+)
FVB/NJ MGP_FVBNJ_G0025174
protein coding gene Chr2:13159627-13554299 (+)
LP/J MGP_LPJ_G0025298
protein coding gene Chr2:13829079-14238515 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025206
protein coding gene Chr2:14895858-15371049 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025842
protein coding gene Chr2:13748673-14173285 (+)
PWK/PhJ MGP_PWKPhJ_G0024315
protein coding gene Chr2:13182685-13590446 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024115
protein coding gene Chr2:13859518-14277381 (+)
WSB/EiJ MGP_WSBEiJ_G0024634
protein coding gene Chr2:13900339-14304057 (+)



Homology
more
  • Human Ortholog
    PLXDC2, plexin domain containing 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXDC2, plexin domain containing 2
  • Synonyms
    PLXDC2-OT, TEM7R
  • Links
    NCBI Gene ID: 84898
    neXtProt AC: NX_Q6UX71
    UniProt: Q6UX71

  • Chr Location
    10p12.31; chr10:19816239-20289856 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Mice homozygous for a hypomorphic reporter allele are viable and behaviorally normal with no apparent abnormalities in the developing and mature nervous system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026748 Ensembl Gene Model | MGI Sequence Detail 399536 C57BL/6J ±  kb
transcript ENSMUST00000028081 Ensembl | MGI Sequence Detail 6947 Not Applicable  
polypeptide ENSMUSP00000028081 Ensembl | MGI Sequence Detail 530 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 8
Other
Accession IDs
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MGI:1921756, MGI:2139026, MGI:2139203, MGI:2139259
References
more
  • Summaries
    All 40
    Developmental Gene Expression 10
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory