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Ikbip Gene Detail
Summary
  • Symbol
    Ikbip
  • Name
    IKBKB interacting protein
  • Synonyms
    1200009F10Rik, 1700023M03Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914704
    NCBI Gene: 67454
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:90918802-90938469 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 45.54 cM, cytoband C2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    679 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914704
 protein coding gene Chr10:90918667-90938475 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017643
 protein coding gene Chr10:92360172-92386137 (+)
A/J MGP_AJ_G0017622
 protein coding gene Chr10:89163437-89185578 (+)
AKR/J MGP_AKRJ_G0017580
 protein coding gene Chr10:91714439-91742763 (+)
BALB/cJ MGP_BALBcJ_G0017585
 protein coding gene Chr10:89448240-89467857 (+)
C3H/HeJ MGP_C3HHeJ_G0017408
 protein coding gene Chr10:91740728-91763051 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018042
 protein coding gene Chr10:95427392-95448514 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015724
 protein coding gene Chr10:84835499-84855626 (+)
CAST/EiJ MGP_CASTEiJ_G0016973
 protein coding gene Chr10:91666262-91689645 (+)
CBA/J MGP_CBAJ_G0017377
 protein coding gene Chr10:99363321-99384990 (+)
DBA/2J MGP_DBA2J_G0017483
 protein coding gene Chr10:88284691-88304078 (+)
FVB/NJ MGP_FVBNJ_G0017475
 protein coding gene Chr10:87506606-87527715 (+)
LP/J MGP_LPJ_G0017557
 protein coding gene Chr10:92994354-93015176 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017506
 protein coding gene Chr10:100815563-100839089 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018079
 protein coding gene Chr10:91614944-91634166 (+)
PWK/PhJ MGP_PWKPhJ_G0016754
 protein coding gene Chr10:88339633-88364515 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016542
 protein coding gene Chr10:90375467-90396862 (+)
WSB/EiJ MGP_WSBEiJ_G0017032
 protein coding gene Chr10:91581723-91603666 (+)



Homology
more
  • Human Ortholog
    IKBIP, IKBKB interacting protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IKBIP, IKBKB interacting protein
  • Synonyms
    IKIP
  • Links
    NCBI Gene ID: 121457
    neXtProt AC: NX_Q70UQ0
    UniProt: Q70UQ0

  • Chr Location
    12q23.1; chr12:98613404-98645113 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with macrophage specific deletion display increased cytokine levels and mortality following LPS challenge and increased sensitivity to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    3
  • cDNA Data
    28
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019975 Ensembl Gene Model | MGI Sequence Detail 19668 C57BL/6J ±  kb
    transcript ENSMUST00000020149 Ensembl | MGI Sequence Detail 3232 Not Applicable  
    polypeptide ENSMUSP00000020149 Ensembl | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008978 inhibitor of nuclear factor kappa-B kinase-interacting protein
      (term hierarchy)
    • InterPro Domains
      IPR024152 Inhibitor of nuclear factor kappa-B kinase-interacting protein
    • GlyGen
      Q9DBZ1 1 site
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 28

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1916685, MGI:2143953
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 9
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:282971 Wu H, et al., IKIP Negatively Regulates NF-kappaB Activation and Inflammation through Inhibition of IKKalpha/beta Phosphorylation. J Immunol. 2020 Jan 15;204(2):418-427
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory