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Ppid Gene Detail
Summary
  • Symbol
    Ppid
  • Name
    peptidylprolyl isomerase D (cyclophilin D)
  • Synonyms
    4930564J03Rik, cyclophilin 40, CYP-40, cytoplasmic cyclophilin D, Ppidl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914988
    NCBI Gene: 67738
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:79498649-79510957 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 34.91 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    441 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914988
 protein coding gene Chr3:79498644-79511117 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027313
 protein coding gene Chr3:79298366-79310648 (+)
A/J MGP_AJ_G0027275
 protein coding gene Chr3:76706461-76718763 (+)
AKR/J MGP_AKRJ_G0027243
 protein coding gene Chr3:78474481-78486829 (+)
BALB/cJ MGP_BALBcJ_G0027286
 protein coding gene Chr3:76735082-76747791 (+)
C3H/HeJ MGP_C3HHeJ_G0027030
 protein coding gene Chr3:78802795-78816122 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027732
 protein coding gene Chr3:82313663-82327213 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025085
 protein coding gene Chr3:72346055-72358631 (+)
CAST/EiJ MGP_CASTEiJ_G0026477
 protein coding gene Chr3:78867296-78879643 (+)
CBA/J MGP_CBAJ_G0027005
 protein coding gene Chr3:85040394-85055518 (+)
DBA/2J MGP_DBA2J_G0027141
 protein coding gene Chr3:76261188-76273583 (+)
FVB/NJ MGP_FVBNJ_G0027109
 protein coding gene Chr3:74603022-74615356 (+)
LP/J MGP_LPJ_G0027249
 protein coding gene Chr3:80267875-80280165 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027128
 protein coding gene Chr3:91292511-91305980 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027790
 protein coding gene Chr3:78311978-78324331 (+)
PWK/PhJ MGP_PWKPhJ_G0026211
 protein coding gene Chr3:76019702-76032818 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026027
 protein coding gene Chr3:77452383-77469974 (+)
WSB/EiJ MGP_WSBEiJ_G0026555
 protein coding gene Chr3:78636830-78649132 (+)



Homology
more
  • Human Ortholog
    PPID, peptidylprolyl isomerase D
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PPID, peptidylprolyl isomerase D
  • Synonyms
    CYP-40, CYPD
  • Links
    NCBI Gene ID: 5481
    neXtProt AC: NX_Q08752
    UniProt: Q08752

  • Chr Location
    4q32.1; chr4:158709127-158723396 (-)  GRCh38
Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a prolyl isomerase dead version of the protein dispay abnormal mitochondrial function and increased susceptibility to myocardial ischemic injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    53
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    1
  • cDNA Data
    13
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027804 Ensembl Gene Model | MGI Sequence Detail 12309 C57BL/6J ±  kb
transcript ENSMUST00000029382 Ensembl | MGI Sequence Detail 1752 Not Applicable  
polypeptide ENSMUSP00000029382 Ensembl | MGI Sequence Detail 370 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000013078 eukaryotic-type peptidyl-prolyl cis-trans isomerase D
    (term hierarchy)
  • EC
    5.2.1.8
  • InterPro Domains
    IPR029000 Cyclophilin-like domain superfamily
    IPR020892 Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site
    IPR002130 Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain
    IPR050754 Immunophilin FKBP-type domain-containing protein
    IPR011990 Tetratricopeptide-like helical domain superfamily
    IPR019734 Tetratricopeptide repeat
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35888, MGI:107419
References
more
  • Summaries
    All 51
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 9
    Phenotypes 15
  • Earliest
    J:34612 Yokoi H, et al., The structure and complete nucleotide sequence of the human cyclophilin 40 (PPID) gene. Genomics. 1996 Aug 1;35(3):448-55
  • Latest
    J:345617 Beutner G, et al., Coordinated metabolic responses to cyclophilin D deletion in the developing heart. iScience. 2024 Mar 15;27(3):109157
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory