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Akr1b10 Gene Detail
Summary
  • Symbol
    Akr1b10
  • Name
    aldo-keto reductase family 1, member B10
  • Synonyms
    2310005E10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915111
    NCBI Gene: 67861
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:34361182-34373884 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 14.93 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    539 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915111
 protein coding gene Chr6:34361153-34373885 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030558
 protein coding gene Chr6:32463947-32477476 (+)
A/J MGP_AJ_G0030531
 protein coding gene Chr6:31080603-31093186 (+)
AKR/J MGP_AKRJ_G0030458
 protein coding gene Chr6:32126218-32146625 (+)
BALB/cJ MGP_BALBcJ_G0030541
 protein coding gene Chr6:31260787-31273645 (+)
C3H/HeJ MGP_C3HHeJ_G0030254
 protein coding gene Chr6:32083615-32096708 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030995
 protein coding gene Chr6:33285646-33298363 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028206
 protein coding gene Chr6:29167317-29180012 (+)
CAST/EiJ MGP_CASTEiJ_G0029656
 protein coding gene Chr6:31905046-31919047 (+)
CBA/J MGP_CBAJ_G0030232
 protein coding gene Chr6:34557636-34570247 (+)
DBA/2J MGP_DBA2J_G0030376
 protein coding gene Chr6:30956406-30969252 (+)
FVB/NJ MGP_FVBNJ_G0030330
 protein coding gene Chr6:30748633-30761572 (+)
LP/J MGP_LPJ_G0030463
 protein coding gene Chr6:32596099-32609597 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030366
 protein coding gene Chr6:36905724-36919459 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031025
 protein coding gene Chr6:32005741-32020469 (+)
PWK/PhJ MGP_PWKPhJ_G0029370
 protein coding gene Chr6:30566319-30580163 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029206
 protein coding gene Chr6:31670789-31676565 (+)
WSB/EiJ MGP_WSBEiJ_G0029732
 protein coding gene Chr6:31920160-31937826 (+)



Homology
more
  • Human Ortholog
    AKR1B10, aldo-keto reductase family 1 member B10
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AKR1B10, aldo-keto reductase family 1 member B10
  • Synonyms
    AKR1B11, AKR1B12, ALDRLn, ARL-1, ARL1, HIS, HSI
  • Links
    NCBI Gene ID: 57016
    neXtProt AC: NX_O60218
    UniProt: O60218

  • Chr Location
    7q33; chr7:134527567-134541412 (+)  GRCh38
  • Human Ortholog
    AKR1B15, aldo-keto reductase family 1 member B15
  • Synonyms
    AKR1B10L, AKR1B10L, AK1R1B7, AKR1R1B7
  • Links
    NCBI Gene ID: 441282
    neXtProt AC: NX_C9JRZ8
    UniProt: C9JRZ8

  • Chr Location
    7q33; chr7:134549110-134579875 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    1
  • cDNA Data
    35
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 67861 NCBI Gene Model | MGI Sequence Detail 12703 C57BL/6J ±  kb
transcript NM_172398 RefSeq | MGI Sequence Detail 1341 C57BL/6  
polypeptide NP_765986 RefSeq | MGI Sequence Detail 316 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • InterPro Domains
    IPR020471 Aldo-keto reductase
    IPR018170 Aldo/keto reductase, conserved site
    IPR023210 NADP-dependent oxidoreductase domain
    IPR036812 NADP-dependent oxidoreductase domain superfamily
  • GlyGen
    G5E895 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 35
    cDNA 35

    Microarray probesets 4
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:200524 Li H, et al., Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10). Carcinogenesis. 2013 Sep;34(9):2090-8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory