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Nifk Gene Detail
Summary
  • Symbol
    Nifk
  • Name
    nucleolar protein interacting with the FHA domain of MKI67
  • Synonyms
    C130020J04Rik, Mki67ip
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915199
    NCBI Gene: 67949
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:118249569-118261552 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 52.14 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    339 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915199
 protein coding gene Chr1:118249569-118261561 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016390
 protein coding gene Chr1:121000548-121012481 (+)
A/J MGP_AJ_G0016373
 protein coding gene Chr1:116688825-116700742 (+)
AKR/J MGP_AKRJ_G0016338
 protein coding gene Chr1:120130415-120143853 (+)
BALB/cJ MGP_BALBcJ_G0016333
 protein coding gene Chr1:116943228-116957766 (+)
C3H/HeJ MGP_C3HHeJ_G0016159
 protein coding gene Chr1:120302071-120313995 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016794
 protein coding gene Chr1:125622028-125633940 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014507
 protein coding gene Chr1:110372442-110384188 (+)
CAST/EiJ MGP_CASTEiJ_G0015740
 protein coding gene Chr1:119025015-119037043 (+)
CBA/J MGP_CBAJ_G0016132
 protein coding gene Chr1:129989243-130001201 (+)
DBA/2J MGP_DBA2J_G0016238
 protein coding gene Chr1:115700473-115712583 (+)
FVB/NJ MGP_FVBNJ_G0016237
 protein coding gene Chr1:114431900-114443816 (+)
LP/J MGP_LPJ_G0016309
 protein coding gene Chr1:122351832-122364094 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016262
 protein coding gene Chr1:135784434-135796376 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016830
 protein coding gene Chr1:119819335-119831274 (+)
PWK/PhJ MGP_PWKPhJ_G0015526
 protein coding gene Chr1:114668787-114680979 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015314
 protein coding gene Chr1:118707357-118719191 (+)
WSB/EiJ MGP_WSBEiJ_G0015802
 protein coding gene Chr1:119717906-119729848 (+)



Homology
more
  • Human Ortholog
    NIFK, nucleolar protein interacting with the FHA domain of MKI67
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NIFK, nucleolar protein interacting with the FHA domain of MKI67
  • Synonyms
    MKI67IP, Nopp34
  • Links
    NCBI Gene ID: 84365
    neXtProt AC: NX_Q9BYG3
    UniProt: Q9BYG3

  • Chr Location
    2q14.3; chr2:121726945-121736911 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    1 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show complete embryonic lethality before implantation. In vitro, embryos fail to hatch from the zona pellucida and die after 3 days in culture, never forming outgrowths.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026377 Ensembl Gene Model | MGI Sequence Detail 11984 C57BL/6J ±  kb
    transcript ENSMUST00000027626 Ensembl | MGI Sequence Detail 1889 Not Applicable  
    polypeptide ENSMUSP00000027626 Ensembl | MGI Sequence Detail 317 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029630 MKI67 FHA domain-interacting nucleolar phosphoprotein
      (term hierarchy)
    • InterPro Domains
      IPR021043 MKI67 FHA domain-interacting nucleolar phosphoprotein, FHA Ki67 binding
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR035979 RNA-binding domain superfamily
      IPR000504 RNA recognition motif domain
    • GlyGen
      Q91VE6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138364
    References
    more
    • Summaries
      All 33
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory