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Srsf6 Gene Detail
Summary
  • Symbol
    Srsf6
  • Name
    serine and arginine-rich splicing factor 6
  • Synonyms
    1210001E11Rik, Sfrs6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915246
    NCBI Gene: 67996
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:162773448-162779041 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 83.87 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    134 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915246
 protein coding gene Chr2:162773428-162779041 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026813
 protein coding gene Chr2:168209371-168214963 (+)
A/J MGP_AJ_G0026779
 protein coding gene Chr2:161465419-161471012 (+)
AKR/J MGP_AKRJ_G0026750
 protein coding gene Chr2:166221985-166230541 (+)
BALB/cJ MGP_BALBcJ_G0026788
 protein coding gene Chr2:161784663-161790256 (+)
C3H/HeJ MGP_C3HHeJ_G0026530
 protein coding gene Chr2:166571570-166578477 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027236
 protein coding gene Chr2:173159180-173164774 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024606
 protein coding gene Chr2:154759664-154765028 (+)
CAST/EiJ MGP_CASTEiJ_G0025991
 protein coding gene Chr2:166931298-166936893 (+)
CBA/J MGP_CBAJ_G0026507
 protein coding gene Chr2:179408259-179418641 (+)
DBA/2J MGP_DBA2J_G0026645
 protein coding gene Chr2:160634991-160641200 (+)
FVB/NJ MGP_FVBNJ_G0026611
 protein coding gene Chr2:159004375-159009882 (+)
LP/J MGP_LPJ_G0026748
 protein coding gene Chr2:168358719-168364311 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026633
 protein coding gene Chr2:183103777-183109371 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027292
 protein coding gene Chr2:166104694-166110288 (+)
PWK/PhJ MGP_PWKPhJ_G0025725
 protein coding gene Chr2:160177206-160183018 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025528
 protein coding gene Chr2:164976791-164984160 (+)
WSB/EiJ MGP_WSBEiJ_G0026061
 protein coding gene Chr2:166975376-166980968 (+)



Homology
more
  • Human Ortholog
    SRSF6, serine and arginine rich splicing factor 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRSF6, serine and arginine rich splicing factor 6
  • Synonyms
    B52, HEL-S-91, SFRS6, SRP55
  • Links
    NCBI Gene ID: 6431
    neXtProt AC: NX_Q13247
    UniProt: Q13247

  • Chr Location
    20q13.11; chr20:43457893-43466046 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SRSF6 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    782
  • Tissues
    30
  • cDNA Data
    17
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016921 Ensembl Gene Model | MGI Sequence Detail 5594 C57BL/6J ±  kb
transcript ENSMUST00000130411 Ensembl | MGI Sequence Detail 3527 Not Applicable  
polypeptide ENSMUSP00000119065 Ensembl | MGI Sequence Detail 339 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    Genomic 2
    cDNA 17
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
less
MGI:2138887, MGI:2147715, MGI:2152843
References
more
  • Summaries
    All 47
    Developmental Gene Expression 6
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:66467 Pazzaglia S, et al., Somatic cell hybrids for high-density mapping of chromosome 2 breakpoints in radiation-induced myeloid leukemia cell lines from inbred mice. Mol Carcinog. 2000 Mar;27(3):219-28
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory