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Bambi Gene Detail
Summary
  • Symbol
    Bambi
  • Name
    BMP and activin membrane-bound inhibitor
  • Synonyms
    2610003H06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915260
    NCBI Gene: 68010
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:3507923-3516404 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 2.30 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    232 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915260
 protein coding gene Chr18:3507011-3516404 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024120
 protein coding gene Chr18:299713-308160 (+)
A/J MGP_AJ_G0024082
 protein coding gene Chr18:347523-355956 (+)
AKR/J MGP_AKRJ_G0024050
 protein coding gene Chr18:350287-358721 (+)
BALB/cJ MGP_BALBcJ_G0024082
 protein coding gene Chr18:375620-384064 (+)
C3H/HeJ MGP_C3HHeJ_G0023847
 protein coding gene Chr18:318004-326450 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024527
 protein coding gene Chr18:390301-398748 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021966
 protein coding gene Chr18:290905-300578 (+)
CAST/EiJ MGP_CASTEiJ_G0023326
 protein coding gene Chr18:315998-324361 (+)
CBA/J MGP_CBAJ_G0023821
 protein coding gene Chr18:360024-368470 (+)
DBA/2J MGP_DBA2J_G0023949
 protein coding gene Chr18:306810-315246 (+)
FVB/NJ MGP_FVBNJ_G0023915
 protein coding gene Chr18:311726-321808 (+)
LP/J MGP_LPJ_G0024033
 protein coding gene Chr18:356806-365253 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023943
 protein coding gene Chr18:364608-373103 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024572
 protein coding gene Chr18:319583-328018 (+)
PWK/PhJ MGP_PWKPhJ_G0023071
 protein coding gene Chr18:349807-358358 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022882
 protein coding gene Chr18:570001-578474 (+)
WSB/EiJ MGP_WSBEiJ_G0023392
 protein coding gene Chr18:337778-346224 (+)



Homology
more
  • Human Ortholog
    BAMBI, BMP and activin membrane bound inhibitor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BAMBI, BMP and activin membrane bound inhibitor
  • Synonyms
    NMA
  • Links
    NCBI Gene ID: 25805
    neXtProt AC: NX_Q13145
    UniProt: Q13145

  • Chr Location
    10p12.1; chr10:28677510-28682932 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BAMBI associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a null allele weigh 9% to 10% less than wild-type female mice. Male mice are unaffected. Mice homozygous for one knock-out allele exhibit increased chemical, thermal, and mechanical nociception and decreased nerve injury-induced allodynia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1397
  • Tissues
    257
  • cDNA Data
    33
  • Literature Summary
    25
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024232 Ensembl Gene Model | MGI Sequence Detail 8482 C57BL/6J ±  kb
    transcript ENSMUST00000025075 Ensembl | MGI Sequence Detail 5074 Not Applicable  
    polypeptide ENSMUSP00000025075 Ensembl | MGI Sequence Detail 260 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000004636 BMP and activin membrane-bound inhibitor
      (term hierarchy)
    • InterPro Domains
      IPR009345 BMP and activin membrane-bound inhibitor
      IPR045806 BMP and activin membrane-bound inhibitor, C-terminal domain
      IPR045807 BMP and activin membrane-bound inhibitor, N-terminal domain
      IPR045860 Snake toxin-like superfamily
    • GlyGen
      Q9D0L6 1 site
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 35
      Primer pair 7

      Microarray probesets 2
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 25
      Gene Ontology 4
      Phenotypes 20
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory