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Nmb Gene Detail
Summary
  • Symbol
    Nmb
  • Name
    neuromedin B
  • Synonyms
    3110023K12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915289
    NCBI Gene: 68039
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80551975-80554810 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.71 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    171 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915289
 protein coding gene Chr7:80551975-80554824 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032421
 protein coding gene Chr7:82912186-82915027 (-)
A/J MGP_AJ_G0032400
 protein coding gene Chr7:80964536-80967373 (-)
AKR/J MGP_AKRJ_G0032336
 protein coding gene Chr7:82732389-82735226 (-)
BALB/cJ MGP_BALBcJ_G0032412
 protein coding gene Chr7:80634191-80637018 (-)
C3H/HeJ MGP_C3HHeJ_G0032125
 protein coding gene Chr7:83372679-83375526 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032904
 protein coding gene Chr7:86159851-86163011 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029912
 protein coding gene Chr7:83470813-83473657 (-)
CAST/EiJ MGP_CASTEiJ_G0031453
 protein coding gene Chr7:74276316-74279157 (-)
CBA/J MGP_CBAJ_G0032091
 protein coding gene Chr7:89029894-89032754 (-)
DBA/2J MGP_DBA2J_G0032246
 protein coding gene Chr7:79511596-79514423 (-)
FVB/NJ MGP_FVBNJ_G0032201
 protein coding gene Chr7:79446095-79448920 (-)
LP/J MGP_LPJ_G0032327
 protein coding gene Chr7:84152881-84155706 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032238
 protein coding gene Chr7:89152233-89155070 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032922
 protein coding gene Chr7:82168566-82171406 (-)
PWK/PhJ MGP_PWKPhJ_G0031173
 protein coding gene Chr7:72716249-72719096 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031014
 protein coding gene Chr7:69186099-69188585 (-)
WSB/EiJ MGP_WSBEiJ_G0031571
 protein coding gene Chr7:82527025-82529846 (-)



Homology
more
  • Human Ortholog
    NMB, neuromedin B
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NMB, neuromedin B
  • Links
    NCBI Gene ID: 4828
    neXtProt AC: NX_P08949
    UniProt: P08949

  • Chr Location
    15q25.2; chr15:84655129-84658563 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human NMB associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knockout allele exhibit attenuated scratching in response to histamine, compound 48/80 and 5-HT.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    39
  • cDNA Data
    19
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 68039 NCBI Gene Model | MGI Sequence Detail 2836 C57BL/6J ±  kb
transcript NM_026523 RefSeq | MGI Sequence Detail 692 Not Specified  
polypeptide Q9CR53 UniProt | EBI | MGI Sequence Detail 121 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 19

    Microarray probesets 3
References
more
  • Summaries
    All 58
    Developmental Gene Expression 6
    Gene Ontology 9
    Phenotypes 22
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory