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Slc25a22 Gene Detail
Summary
  • Symbol
    Slc25a22
  • Name
    solute carrier family 25 (mitochondrial carrier, glutamate), member 22
  • Synonyms
    1300006L01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915517
    NCBI Gene: 68267
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:141009662-141017787 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 86.78 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915517
 protein coding gene Chr7:141009657-141017805 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033229
 protein coding gene Chr7:146618388-146626536 (-)
A/J MGP_AJ_G0033211
 protein coding gene Chr7:142423653-142431801 (-)
AKR/J MGP_AKRJ_G0033143
 protein coding gene Chr7:146373824-146381972 (-)
BALB/cJ MGP_BALBcJ_G0033212
 protein coding gene Chr7:142168840-142176988 (-)
C3H/HeJ MGP_C3HHeJ_G0032926
 protein coding gene Chr7:146114031-146122179 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033723
 protein coding gene Chr7:151969748-151977896 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030696
 protein coding gene Chr7:143635797-143643897 (-)
CAST/EiJ MGP_CASTEiJ_G0032256
 protein coding gene Chr7:138426020-138434163 (-)
CBA/J MGP_CBAJ_G0032898
 protein coding gene Chr7:157134085-157142231 (-)
DBA/2J MGP_DBA2J_G0033050
 protein coding gene Chr7:140372054-140380202 (-)
FVB/NJ MGP_FVBNJ_G0033003
 protein coding gene Chr7:140286421-140294805 (-)
LP/J MGP_LPJ_G0033145
 protein coding gene Chr7:148114421-148122569 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033036
 protein coding gene Chr7:157764944-157773092 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033743
 protein coding gene Chr7:145332352-145340500 (-)
PWK/PhJ MGP_PWKPhJ_G0031960
 protein coding gene Chr7:133656229-133664371 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031807
 protein coding gene Chr7:132169266-132177405 (-)
WSB/EiJ MGP_WSBEiJ_G0032367
 protein coding gene Chr7:146282895-146291078 (-)



Homology
more
  • Human Ortholog
    SLC25A22, solute carrier family 25 member 22
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC25A22, solute carrier family 25 member 22
  • Synonyms
    DEE3, EIEE3, GC-1, GC1, NET44
  • Links
    NCBI Gene ID: 79751
    neXtProt AC: NX_Q9H936
    UniProt: Q9H936

  • Chr Location
    11p15.5; chr11:790475-798281 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC25A22 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    874
  • Tissues
    111
  • cDNA Data
    108
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68267 NCBI Gene Model | MGI Sequence Detail 8126 C57BL/6J ±  kb
transcript NM_001360724 RefSeq | MGI Sequence Detail 2807 C57BL/6  
polypeptide Q9D6M3 UniProt | EBI | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    15 Sequences
  • Protein Ontology
    PR:000015018 mitochondrial glutamate carrier 1
    (term hierarchy)
  • InterPro Domains
    IPR023395 Mitochondrial carrier domain superfamily
    IPR002067 Mitochondrial carrier protein
    IPR051028 Mitochondrial Solute Carrier
    IPR018108 Mitochondrial substrate/solute carrier
  • GlyGen
    Q9D6M3 3 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 108
    cDNA 108

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141864
References
more
  • Summaries
    All 47
    Developmental Gene Expression 3
    Gene Ontology 7
    Phenotypes 12
  • Earliest
    J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory