About   Help   FAQ
Stn1 Gene Detail
Summary
  • Symbol
    Stn1
  • Name
    STN1, CST complex subunit
  • Synonyms
    0610009H20Rik, 2310057J23Rik, Obfc1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915581
    NCBI Gene: 108689
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:47489472-47525946 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 39.64 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1405 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915581
 protein coding gene Chr19:47489470-47534284 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025230
 protein coding gene Chr19:47321193-47357785 (-)
A/J MGP_AJ_G0025206
 protein coding gene Chr19:44948735-44985726 (-)
AKR/J MGP_AKRJ_G0025175
 protein coding gene Chr19:46415087-46456474 (-)
BALB/cJ MGP_BALBcJ_G0025201
 protein coding gene Chr19:45004348-45040938 (-)
C3H/HeJ MGP_C3HHeJ_G0024961
 protein coding gene Chr19:46599838-46638949 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025644
 protein coding gene Chr19:48448588-48488625 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023057
 protein coding gene Chr19:44179933-44217199 (-)
CAST/EiJ MGP_CASTEiJ_G0024426
 protein coding gene Chr19:46424525-46462321 (-)
CBA/J MGP_CBAJ_G0024941
 protein coding gene Chr19:50899258-50955104 (-)
DBA/2J MGP_DBA2J_G0025073
 protein coding gene Chr19:44756682-44795151 (-)
FVB/NJ MGP_FVBNJ_G0025034
 protein coding gene Chr19:44556926-44593660 (-)
LP/J MGP_LPJ_G0025159
 protein coding gene Chr19:47211869-47252420 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025065
 protein coding gene Chr19:50156911-50198987 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025702
 protein coding gene Chr19:46534926-46572193 (-)
PWK/PhJ MGP_PWKPhJ_G0024175
 protein coding gene Chr19:44731509-44770641 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023978
 protein coding gene Chr19:45190230-45230162 (-)
WSB/EiJ MGP_WSBEiJ_G0024496
 protein coding gene Chr19:46691354-46730507 (-)



Homology
more
  • Human Ortholog
    STN1, STN1 subunit of CST complex
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    STN1, STN1 subunit of CST complex
  • Synonyms
    AAF-44, AAF44, bA541N10.2, OBFC1, RPA-32
  • Links
    NCBI Gene ID: 79991
    neXtProt AC: NX_Q9H668
    UniProt: Q9H668

  • Chr Location
    10q24.33; chr10:103856806-103918332 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human STN1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000042694 Ensembl Gene Model | MGI Sequence Detail 36475 C57BL/6J ±  kb
transcript ENSMUST00000049369 Ensembl | MGI Sequence Detail 1992 Not Applicable  
polypeptide ENSMUSP00000040944 Ensembl | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000011582 oligonucleotide/oligosaccharide-binding fold-containing protein 1
    (term hierarchy)
  • PDB
    1WJ5
  • InterPro Domains
    IPR014647 CST complex subunit Stn1
    IPR018856 CST complex subunit Stn1, N-terminal
    IPR042082 CST complex subunit Stn1, wHTH1 motif superfamily
    IPR012340 Nucleic acid-binding, OB-fold
    IPR040260 Replication factor A protein-like
    IPR015253 Stn1, C-terminal
    IPR036390 Winged helix DNA-binding domain superfamily
    IPR036388 Winged helix-like DNA-binding domain superfamily
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916898, MGI:2147515
References
more
  • Summaries
    All 32
    Gene Ontology 8
    Phenotypes 4
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:335558 Nguyen DD, et al., Deficiency in mammalian STN1 promotes colon cancer development via inhibiting DNA repair. Sci Adv. 2023 May 10;9(19):eadd8023
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory