Crip2 MGI Mouse Gene Detail - MGI:1915587

Symbol

Crip2
Name

cysteine rich protein 2
Synonyms

0610010I23Rik, Crp, CRP4, ESP1, Hlp

Feature Type

protein coding gene
IDs

MGI:1915587
NCBI Gene: 68337
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr12:113103856-113109126 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.57 cM
Mapping Data

4 experiments

Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1915587	protein coding gene	Chr12:113103856-113109126 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020172	protein coding gene	Chr12:115636623-115641557 (+)
A/J	MGP_AJ_G0020128	protein coding gene	Chr12:111158458-111163713 (+)
AKR/J	MGP_AKRJ_G0020103	protein coding gene	Chr12:114389986-114394920 (+)
BALB/cJ	MGP_BALBcJ_G0020113	protein coding gene	Chr12:111624279-111629213 (+)
C3H/HeJ	MGP_C3HHeJ_G0019915	protein coding gene	Chr12:114911615-114916870 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020558	protein coding gene	Chr12:119182003-119186937 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018172	protein coding gene	Chr12:107592280-107597630 (+)
CAST/EiJ	MGP_CASTEiJ_G0019455	protein coding gene	Chr12:109755977-109762078 (+)
CBA/J	MGP_CBAJ_G0019882	protein coding gene	Chr12:123749679-123754934 (+)
DBA/2J	MGP_DBA2J_G0019999	protein coding gene	Chr12:110659893-110664827 (+)
FVB/NJ	MGP_FVBNJ_G0019984	protein coding gene	Chr12:109503213-109508468 (+)
LP/J	MGP_LPJ_G0020073	protein coding gene	Chr12:115456957-115461891 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020022	protein coding gene	Chr12:126836568-126841502 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020587	protein coding gene	Chr12:113906374-113911629 (+)
PWK/PhJ	MGP_PWKPhJ_G0019217	protein coding gene	Chr12:105321277-105326759 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019021	protein coding gene	Chr12:108086383-108091642 (+)
WSB/EiJ	MGP_WSBEiJ_G0019515	protein coding gene	Chr12:114820616-114825871 (+)

Human Ortholog

CRIP2, cysteine rich protein 2

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CRIP2, cysteine rich protein 2
Synonyms

CRIP, CRP2, ESP1
Links

HGNC:2361

NCBI Gene ID: 1397

neXtProt AC: NX_P52943

UniProt: P52943
Chr Location

14q32.33; chr14:105472945-105480170 (+) GRCh38

MGI Vertebrate Homology

Crip2 stringent orthology
1 human;1 mouse;2 rat;2 zebrafish
HCOP

vertebrate homology predictions: CRIP2
Gene Tree

Crip2

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Endonuclease-mediated

2
Gene trapped

3
Targeted

6
Incidental Mutations

Mutagenetix
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for a null allele display abnormal inflammatory pain responses.

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All GO Annotations

5
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

919
Tissues

149
cDNA Data

10
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CRIP2

Xenbase crip2

ZFIN crip2

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All Sequences

51
RefSeq

6
UniProt

3
CCDS

CCDS26204.1, CCDS84005.1

Ensembl

ENSMUSG00000006356 (Evidence)
NCBI Gene

68337

			Length	Strain/Species	Flank
genomic	68337	NCBI Gene Model \| MGI Sequence Detail	5271	C57BL/6J	± kb
transcript	NM_024223	RefSeq \| MGI Sequence Detail	1454	ZRU/MplStud
polypeptide	Q9DCT8	UniProt \| EBI \| MGI Sequence Detail	208	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000005874 cysteine-rich protein 2

(term hierarchy)
InterPro Domains

IPR001781 Zinc finger, LIM-type
GlyGen

Q9DCT8 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 15

cDNA 10

Primer pair 4

Other 1

Microarray probesets 3

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MGI:2145057, MGI:2145082

Summaries

All 51

Developmental Gene Expression 12

Gene Ontology 3

Phenotypes 14
Earliest

J:31705 Karim MA, et al., Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3. Genomics. 1996 Jan 15;31(2):167-76
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Crip2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115476	Chr12:113103818-113103877 (+)	-8 bp
Tssr115477	Chr12:113104093-113104102 (+)	242 bp
Tssr115478	Chr12:113104120-113104185 (+)	297 bp
Tssr115479	Chr12:113104186-113104197 (+)	336 bp
Tssr3963	Chr12:113104212-113104219 (+)	360 bp
Tssr3964	Chr12:113104223-113104228 (+)	370 bp
Tssr3965	Chr12:113104286-113104290 (+)	432 bp
Tssr3966	Chr12:113104327-113104338 (+)	477 bp
Tssr115480	Chr12:113105124-113105129 (+)	1,271 bp
Tssr115481	Chr12:113106385-113106443 (+)	2,558 bp
Tssr115482	Chr12:113106456-113106481 (+)	2,613 bp
Tssr115483	Chr12:113106484-113106500 (+)	2,636 bp
Tssr115484	Chr12:113107130-113107167 (+)	3,293 bp
Tssr115485	Chr12:113107644-113107657 (+)	3,795 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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