About   Help   FAQ
Rraga Gene Detail
Summary
  • Symbol
    Rraga
  • Name
    Ras-related GTP binding A
  • Synonyms
    1300010C19Rik, FIP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915691
    NCBI Gene: 68441
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:86493910-86495522 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 40.69 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915691
 protein coding gene Chr4:86493905-86495522 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028411
 protein coding gene Chr4:86338250-86339867 (+)
A/J MGP_AJ_G0028372
 protein coding gene Chr4:83330925-83332543 (+)
AKR/J MGP_AKRJ_G0028321
 protein coding gene Chr4:85430137-85431754 (+)
BALB/cJ MGP_BALBcJ_G0028392
 protein coding gene Chr4:83514082-83515700 (+)
C3H/HeJ MGP_C3HHeJ_G0028107
 protein coding gene Chr4:86078990-86080608 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028831
 protein coding gene Chr4:89609861-89611479 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026131
 protein coding gene Chr4:79424458-79426067 (+)
CAST/EiJ MGP_CASTEiJ_G0027548
 protein coding gene Chr4:83982615-83984232 (+)
CBA/J MGP_CBAJ_G0028076
 protein coding gene Chr4:92396787-92398405 (+)
DBA/2J MGP_DBA2J_G0028225
 protein coding gene Chr4:83074806-83076423 (+)
FVB/NJ MGP_FVBNJ_G0028191
 protein coding gene Chr4:82062640-82064257 (+)
LP/J MGP_LPJ_G0028325
 protein coding gene Chr4:86673329-86674946 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028220
 protein coding gene Chr4:97450215-97451832 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028868
 protein coding gene Chr4:85503901-85505519 (+)
PWK/PhJ MGP_PWKPhJ_G0027271
 protein coding gene Chr4:81420108-81421723 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027096
 protein coding gene Chr4:83056648-83058275 (+)
WSB/EiJ MGP_WSBEiJ_G0027624
 protein coding gene Chr4:85688221-85689837 (+)



Homology
more
  • Human Ortholog
    RRAGA, Ras related GTP binding A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RRAGA, Ras related GTP binding A
  • Synonyms
    FIP-1, FIP1, RAGA
  • Links
    NCBI Gene ID: 10670
    neXtProt AC: NX_Q7L523
    UniProt: Q7L523

  • Chr Location
    9p22.1; chr9:19049427-19051025 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 4 alleles in 5 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations display embryonic lethality during organogenesis, impaired growth and open neural tubes. Mice homozygous for a constitutively active knock-in allele exhibit neonatal lethality associated with impaired hepatic gluconeogenesis and impaired autophagy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    717
  • Tissues
    7
  • cDNA Data
    69
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68441 NCBI Gene Model | MGI Sequence Detail 1613 C57BL/6J ±  kb
    transcript NM_178376 RefSeq | MGI Sequence Detail 1653 C57BL/6  
    polypeptide Q80X95 UniProt | EBI | MGI Sequence Detail 313 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 70
      cDNA 70

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:2140212
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 21
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:349365 Samson N, et al., HSDL2 links nutritional cues to bile acid and cholesterol homeostasis. Sci Adv. 2024 May 31;10(22):eadk9681
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory