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Cthrc1 Gene Detail
Summary
  • Symbol
    Cthrc1
  • Name
    collagen triple helix repeat containing 1
  • Synonyms
    1110014B07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915838
    NCBI Gene: 68588
  • Alliance
  • Transcription Start Sites
    2 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr15:38940327-38950516 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 15.35 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    136 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915838
protein coding gene Chr15:38940327-38950516 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021812
protein coding gene Chr15:37496406-37506724 (+)
A/J MGP_AJ_G0021772
protein coding gene Chr15:36042215-36058625 (+)
AKR/J MGP_AKRJ_G0021753
protein coding gene Chr15:37123618-37133728 (+)
BALB/cJ MGP_BALBcJ_G0021779
protein coding gene Chr15:36083705-36094182 (+)
C3H/HeJ MGP_C3HHeJ_G0021553
protein coding gene Chr15:37055337-37066231 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022218
protein coding gene Chr15:38935815-38945911 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019755
protein coding gene Chr15:33801089-33809652 (+)
CAST/EiJ MGP_CASTEiJ_G0021070
protein coding gene Chr15:37493447-37504043 (+)
CBA/J MGP_CBAJ_G0021522
protein coding gene Chr15:40295055-40306598 (+)
DBA/2J MGP_DBA2J_G0021646
protein coding gene Chr15:35876793-35886812 (+)
FVB/NJ MGP_FVBNJ_G0021624
protein coding gene Chr15:35283621-35293729 (+)
LP/J MGP_LPJ_G0021716
protein coding gene Chr15:37365192-37375499 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021648
protein coding gene Chr15:43168639-43180905 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022241
protein coding gene Chr15:37252797-37263814 (+)
PWK/PhJ MGP_PWKPhJ_G0020815
protein coding gene Chr15:35936244-35946680 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020652
protein coding gene Chr15:36944294-36955541 (+)
WSB/EiJ MGP_WSBEiJ_G0021125
protein coding gene Chr15:37195190-37206402 (+)



Homology
more
  • Human Ortholog
    CTHRC1, collagen triple helix repeat containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTHRC1, collagen triple helix repeat containing 1
  • Links
    NCBI Gene ID: 115908
    neXtProt AC: NX_Q96CG8
    UniProt: Q96CG8

  • Chr Location
    8q22.3; chr8:103371538-103382989 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CTHRC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 7 alleles in 9 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Adult mice homozygous for a null allele exhibit decreased bone, decreased osteoblast number and decreased bone formation. Mice homozygous for a different knock-out allele exhibit increased hepatocyte size, decreased cell density in the liver, hepatic steatosis and increased glycogen storage.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68588 NCBI Gene Model | MGI Sequence Detail 10190 C57BL/6J ±  kb
    transcript NM_026778 RefSeq | MGI Sequence Detail 1182 C57BL/6  
    polypeptide Q9D1D6 UniProt | EBI | MGI Sequence Detail 245 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 21
      Primer pair 4
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 18
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:358260 Tsukui T, et al., Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis. Nature. 2024 Jul;631(8021):627-634

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    12/10/2024
    MGI 6.24
    The Jackson Laboratory