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Syf2 Gene Detail
Summary
  • Symbol
    Syf2
  • Name
    SYF2 homolog, RNA splicing factor (S. cerevisiae)
  • Synonyms
    1110018L13Rik, Cbpin, D4Bwg1551e, Gcipip, mp29, Ntc31, p29
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915842
    NCBI Gene: 68592
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:134658291-134664848 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 67.15 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915842
 protein coding gene Chr4:134658209-134664859 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028938
 protein coding gene Chr4:137320492-137327136 (+)
A/J MGP_AJ_G0028897
 protein coding gene Chr4:131539923-131546619 (+)
AKR/J MGP_AKRJ_G0028849
 protein coding gene Chr4:135328148-135334778 (+)
BALB/cJ MGP_BALBcJ_G0028921
 protein coding gene Chr4:132192299-132198913 (+)
C3H/HeJ MGP_C3HHeJ_G0028635
 protein coding gene Chr4:135567157-135573805 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029362
 protein coding gene Chr4:142270512-142277075 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026633
 protein coding gene Chr4:124591035-124599021 (+)
CAST/EiJ MGP_CASTEiJ_G0028067
 protein coding gene Chr4:133694689-133703141 (+)
CBA/J MGP_CBAJ_G0028600
 protein coding gene Chr4:146046969-146053605 (+)
DBA/2J MGP_DBA2J_G0028749
 protein coding gene Chr4:131960119-131966733 (+)
FVB/NJ MGP_FVBNJ_G0028716
 protein coding gene Chr4:130871803-130878428 (+)
LP/J MGP_LPJ_G0028848
 protein coding gene Chr4:137431175-137437715 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028742
 protein coding gene Chr4:150477655-150484323 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029400
 protein coding gene Chr4:135763041-135769684 (+)
PWK/PhJ MGP_PWKPhJ_G0027787
 protein coding gene Chr4:128709302-128716284 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027613
 protein coding gene Chr4:131591479-131597286 (+)
WSB/EiJ MGP_WSBEiJ_G0028145
 protein coding gene Chr4:135935746-135942366 (+)



Homology
more
  • Human Ortholog
    SYF2, SYF2 pre-mRNA splicing factor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYF2, SYF2 pre-mRNA splicing factor
  • Synonyms
    CBPIN, fSAP29, NTC31, P29
  • Links
    NCBI Gene ID: 25949
    neXtProt AC: NX_O95926
    UniProt: O95926

  • Chr Location
    1p36.11; chr1:25222276-25232502 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele fail to undergo normal gastrulation and exhibit complete embryonic lethality, severely impaired embryonic development, and abnormal cell cycle checkpoint function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    726
  • Tissues
    3
  • cDNA Data
    134
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 68592 NCBI Gene Model | MGI Sequence Detail 6558 C57BL/6J ±  kb
transcript NM_026780 RefSeq | MGI Sequence Detail 1276 ZRU/MplStud  
polypeptide Q9D198 UniProt | EBI | MGI Sequence Detail 242 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 136
    cDNA 134
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-35798, MGI:107332
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 9
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory