About   Help   FAQ
Abhd4 Gene Detail
Summary
  • Symbol
    Abhd4
  • Name
    abhydrolase domain containing 4
  • Synonyms
    1110035H23Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1915938
    NCBI Gene: 105501
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54491586-54506626 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.71 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    424 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1915938
 protein coding gene Chr14:54491586-54508094 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021304
 protein coding gene Chr14:48188834-48207177 (+)
A/J MGP_AJ_G0021263
 protein coding gene Chr14:47275210-47291389 (+)
AKR/J MGP_AKRJ_G0021239
 protein coding gene Chr14:48986246-49002457 (+)
BALB/cJ MGP_BALBcJ_G0021267
 protein coding gene Chr14:47246623-47262772 (+)
C3H/HeJ MGP_C3HHeJ_G0021047
 protein coding gene Chr14:48665565-48683019 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021706
 protein coding gene Chr14:50657583-50668927 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019250
 protein coding gene Chr14:45688703-45705007 (+)
CAST/EiJ MGP_CASTEiJ_G0020566
 protein coding gene Chr14:44901124-44917508 (+)
CBA/J MGP_CBAJ_G0021014
 protein coding gene Chr14:52145147-52162142 (+)
DBA/2J MGP_DBA2J_G0021135
 protein coding gene Chr14:47021171-47038095 (+)
FVB/NJ MGP_FVBNJ_G0021117
 protein coding gene Chr14:46473468-46489509 (+)
LP/J MGP_LPJ_G0021209
 protein coding gene Chr14:49215814-49233370 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021141
 protein coding gene Chr14:51584807-51602812 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021732
 protein coding gene Chr14:48165584-48183977 (+)
PWK/PhJ MGP_PWKPhJ_G0020312
 protein coding gene Chr14:43543764-43560307 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020140
 protein coding gene Chr14:44149455-44182821 (+)
WSB/EiJ MGP_WSBEiJ_G0020619
 protein coding gene Chr14:48459746-48475914 (+)



Homology
more
  • Human Ortholog
    ABHD4, abhydrolase domain containing 4, N-acyl phospholipase B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABHD4, abhydrolase domain containing 4, N-acyl phospholipase B
  • Synonyms
    ABH4
  • Links
    NCBI Gene ID: 63874
    neXtProt AC: NX_Q8TB40
    UniProt: Q8TB40

  • Chr Location
    14q11.2; chr14:22598290-22612963 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are viable, healthy and behaviorally normal but show deregulated N-acyl phospholipid metabolism in brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    847
  • Tissues
    60
  • cDNA Data
    127
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 105501 NCBI Gene Model | MGI Sequence Detail 15041 C57BL/6J ±  kb
transcript NM_001205181 RefSeq | MGI Sequence Detail 2661 C57BL/6  
polypeptide Q8VD66 UniProt | EBI | MGI Sequence Detail 342 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 127
    cDNA 127

    Microarray probesets 4
Other
Accession IDs
less
MGI:2145640
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory