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Ssu72 Gene Detail
Summary
  • Symbol
    Ssu72
  • Name
    Ssu72 RNA polymerase II CTD phosphatase homolog (yeast)
  • Synonyms
    1190002E22Rik, 1500011L16Rik, 2610101M12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916241
    NCBI Gene: 68991
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:155789272-155818336 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 87.07 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916241
 protein coding gene Chr4:155789257-155818336 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029223
 protein coding gene Chr4:160056637-160088894 (+)
A/J MGP_AJ_G0029188
 protein coding gene Chr4:153322684-153352209 (+)
AKR/J MGP_AKRJ_G0029136
 protein coding gene Chr4:157489810-157518310 (+)
BALB/cJ MGP_BALBcJ_G0029204
 protein coding gene Chr4:153791217-153823904 (+)
C3H/HeJ MGP_C3HHeJ_G0028925
 protein coding gene Chr4:158036473-158066563 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029653
 protein coding gene Chr4:165734010-165771926 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026898
 protein coding gene Chr4:145608831-145638620 (+)
CAST/EiJ MGP_CASTEiJ_G0028337
 protein coding gene Chr4:155491834-155525914 (+)
CBA/J MGP_CBAJ_G0028887
 protein coding gene Chr4:170739542-170778877 (+)
DBA/2J MGP_DBA2J_G0029036
 protein coding gene Chr4:153342478-153372104 (+)
FVB/NJ MGP_FVBNJ_G0028999
 protein coding gene Chr4:152587162-152617403 (+)
LP/J MGP_LPJ_G0029126
 protein coding gene Chr4:159969476-160001920 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029026
 protein coding gene Chr4:173554968-173588708 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029685
 protein coding gene Chr4:158119562-158151228 (+)
PWK/PhJ MGP_PWKPhJ_G0028058
 protein coding gene Chr4:149481332-149510980 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027892
 protein coding gene Chr4:152373243-152403533 (+)
WSB/EiJ MGP_WSBEiJ_G0028417
 protein coding gene Chr4:158287105-158317233 (+)



Homology
more
  • Human Ortholog
    SSU72, SSU72 homolog, RNA polymerase II CTD phosphatase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SSU72, SSU72 homolog, RNA polymerase II CTD phosphatase
  • Synonyms
    HSPC182, PNAS-120
  • Links
    NCBI Gene ID: 29101
    neXtProt AC: NX_Q9NP77
    UniProt: Q9NP77

  • Chr Location
    1p36.33; chr1:1541673-1574863 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Ssu72 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with liver-specific deletion show impaired regulation of hepatocyte chromosome polyploidization, impaired liver damage response with fibrosis, steatosis and steatohepatitis, and deregulation of hepatocyte cell cycle progression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    720
  • Tissues
    3
  • cDNA Data
    13
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 68991 NCBI Gene Model | MGI Sequence Detail 29065 C57BL/6J ±  kb
    transcript NM_026899 RefSeq | MGI Sequence Detail 1478 C57BL/6  
    polypeptide Q9CY97 UniProt | EBI | MGI Sequence Detail 194 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 13
      cDNA 13

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1916122, MGI:1926086
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory