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Cnot8 Gene Detail
Summary
  • Symbol
    Cnot8
  • Name
    CCR4-NOT transcription complex, subunit 8
  • Synonyms
    1500015I04Rik, 1810022F04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1916375
    NCBI Gene: 69125
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:57994979-58009420 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 35.69 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    364 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1916375
 protein coding gene Chr11:57983620-58009423 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018342
 protein coding gene Chr11:57773939-57789871 (+)
A/J MGP_AJ_G0018312
 protein coding gene Chr11:55579592-55599561 (+)
AKR/J MGP_AKRJ_G0018281
 protein coding gene Chr11:57417449-57431970 (+)
BALB/cJ MGP_BALBcJ_G0018283
 protein coding gene Chr11:55930184-55946228 (+)
C3H/HeJ MGP_C3HHeJ_G0018094
 protein coding gene Chr11:57341082-57356222 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018734
 protein coding gene Chr11:59544161-59561508 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016384
 protein coding gene Chr11:52939865-52954455 (+)
CAST/EiJ MGP_CASTEiJ_G0017659
 protein coding gene Chr11:57441467-57459414 (+)
CBA/J MGP_CBAJ_G0018069
 protein coding gene Chr11:62296397-62315720 (+)
DBA/2J MGP_DBA2J_G0018178
 protein coding gene Chr11:55236672-55251451 (+)
FVB/NJ MGP_FVBNJ_G0018169
 protein coding gene Chr11:54933649-54948819 (+)
LP/J MGP_LPJ_G0018253
 protein coding gene Chr11:58312922-58328654 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018195
 protein coding gene Chr11:63420268-63435726 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018777
 protein coding gene Chr11:57440817-57460868 (+)
PWK/PhJ MGP_PWKPhJ_G0017431
 protein coding gene Chr11:55838540-55853906 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017226
 protein coding gene Chr11:57336734-57349653 (+)
WSB/EiJ MGP_WSBEiJ_G0017706
 protein coding gene Chr11:57091367-57106890 (+)



Homology
more
  • Human Ortholog
    CNOT8, CCR4-NOT transcription complex subunit 8
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CNOT8, CCR4-NOT transcription complex subunit 8
  • Synonyms
    CAF1, Caf1b, CALIF, hCAF1, POP2
  • Links
    NCBI Gene ID: 9337
    neXtProt AC: NX_Q9UFF9
    UniProt: Q9UFF9

  • Chr Location
    5q33.2; chr5:154857553-154876792 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit lethality prior to E10.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    773
  • Tissues
    48
  • cDNA Data
    176
  • Literature Summary
    10
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020515 Ensembl Gene Model | MGI Sequence Detail 14442 C57BL/6J ±  kb
transcript ENSMUST00000020822 Ensembl | MGI Sequence Detail 2035 Not Applicable  
polypeptide ENSMUSP00000020822 Ensembl | MGI Sequence Detail 292 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 178
    cDNA 176
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923593, MGI:2142427, MGI:2144376, MGI:2144436
References
more
  • Summaries
    All 51
    Developmental Gene Expression 10
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:343009 Soeda S, et al., The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs. Development. 2023 Nov 1;150(21):dev201773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory