Srsf11 MGI Mouse Gene Detail - MGI:1916457 - serine and arginine-rich splicing factor 11

Symbol

Srsf11
Name

serine and arginine-rich splicing factor 11
Synonyms

0610009J05Rik, 2610019N13Rik, Sfrs11

Feature Type

protein coding gene
IDs

MGI:1916457
NCBI Gene: 69207
Alliance

gene page
Transcription Start Sites

12 TSS

Sequence Map

Chr3:157716552-157742304 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 81.63 cM, cytoband H4
Mapping Data

3 experiments

SNPs within 2kb

420 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1916457	protein coding gene	Chr3:157716110-157742304 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028015	protein coding gene	Chr3:162166863-162194841 (-)
A/J	MGP_AJ_G0027973	protein coding gene	Chr3:156258405-156284640 (-)
AKR/J	MGP_AKRJ_G0027939	protein coding gene	Chr3:160407295-160434646 (-)
BALB/cJ	MGP_BALBcJ_G0027985	protein coding gene	Chr3:156071846-156098006 (-)
C3H/HeJ	MGP_C3HHeJ_G0027715	protein coding gene	Chr3:160807439-160833679 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028428	protein coding gene	Chr3:167485114-167511592 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025767	protein coding gene	Chr3:150868684-150894612 (-)
CAST/EiJ	MGP_CASTEiJ_G0027168	protein coding gene	Chr3:160950353-160979889 (-)
CBA/J	MGP_CBAJ_G0027690	protein coding gene	Chr3:173429594-173458085 (-)
DBA/2J	MGP_DBA2J_G0027830	protein coding gene	Chr3:155306200-155332415 (-)
FVB/NJ	MGP_FVBNJ_G0027797	protein coding gene	Chr3:152656677-152682811 (-)
LP/J	MGP_LPJ_G0027941	protein coding gene	Chr3:163495971-163525685 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027830	protein coding gene	Chr3:182016454-182043179 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028487	protein coding gene	Chr3:160087030-160113210 (-)
PWK/PhJ	MGP_PWKPhJ_G0026891	protein coding gene	Chr3:155234199-155261495 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026719	protein coding gene	Chr3:158301321-158327464 (-)
WSB/EiJ	MGP_WSBEiJ_G0027248	protein coding gene	Chr3:161050861-161077497 (-)

Human Ortholog

SRSF11, serine and arginine rich splicing factor 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SRSF11, serine and arginine rich splicing factor 11
Synonyms

dJ677H15.2, NET2, p54, SFRS11
Links

HGNC:10782

NCBI Gene ID: 9295

neXtProt AC: NX_Q05519

UniProt: Q05519
Chr Location

1p31.1; chr1:70205682-70253052 (+) GRCh38

MGI Vertebrate Homology

Srsf11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SRSF11
Gene Tree

Srsf11

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Endonuclease-mediated

1
Gene trapped

37
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

68 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

4
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

791
Tissues

69
cDNA Data

26
Literature Summary

6

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase srsf11

ZFIN srsf11

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All Sequences

186
RefSeq

78
UniProt

19
CCDS

CCDS17934.1, CCDS51102.1, CCDS51103.1

Ensembl

ENSMUSG00000055436 (Evidence)
NCBI Gene

69207

			Length	Strain/Species	Flank
genomic	69207	NCBI Gene Model \| MGI Sequence Detail	25753	C57BL/6J	± kb
transcript	NR_166757	RefSeq \| MGI Sequence Detail	2986	C57BL/6
polypeptide	NP_001366462	RefSeq \| MGI Sequence Detail	483	C57BL/6

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UniProt

19 Sequences
InterPro Domains

IPR012677 Nucleotide-binding alpha-beta plait domain superfamily

IPR035979 RNA-binding domain superfamily

IPR000504 RNA recognition motif domain

IPR034447 Serine/arginine-rich splicing factor 11, RRM
GlyGen

Q3UIX4 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 28

cDNA 26

Primer pair 1

Other 1

Microarray probesets 9

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MGI:1921339, MGI:2683641

Summaries

All 45

Developmental Gene Expression 6

Gene Ontology 2

Phenotypes 15
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Srsf11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr36307	Chr3:157742267-157742284 (-)	28 bp
Tssr36306	Chr3:157742203-157742266 (-)	69 bp
Tssr36305	Chr3:157742182-157742202 (-)	112 bp
Tssr36304	Chr3:157737342-157737411 (-)	4,927 bp
Tssr36303	Chr3:157737285-157737328 (-)	4,997 bp
Tssr36302	Chr3:157734876-157734881 (-)	7,425 bp
Tssr36301	Chr3:157730322-157730332 (-)	11,977 bp
Tssr36300	Chr3:157729642-157729661 (-)	12,652 bp
Tssr36299	Chr3:157727037-157727067 (-)	15,252 bp
Tssr36298	Chr3:157722056-157722072 (-)	20,240 bp
Tssr1106	Chr3:157722005-157722020 (-)	20,291 bp
Tssr36297	Chr3:157721983-157721996 (-)	20,314 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24